Platelet Count in First Trimester of Pregnancy as a Predictor of Perinatal Outcome
| Autor: | Juan Antonio de León Luis, Virginia Ortega Abad, Pilar Pintado Recarte, Ricardo Pérez Fernández Pacheco, Santiago Garcia-Tizon Larroca, Alejandro Garcia Carreras, Cesar Rodriguez Hernandez, Gonzalo Nozaleda Pastor, Juan Arévalo-Serrano |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
lcsh:Medicine Perinatal outcome 030204 cardiovascular system & hematology 03 medical and health sciences Platelet Count Pregnancy Trimester First Pregnancy Outcome 0302 clinical medicine medicine Cardiotocography Platelet Pregnancy 030219 obstetrics & reproductive medicine medicine.diagnostic_test Obstetrics business.industry lcsh:R Obstetrics and Gynecology General Medicine Clinical Science medicine.disease Perinatology First trimester Gestation Population study Multiple linear regression analysis sense organs business |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences; Vol. 5 No. 1 (2017): Feb 15 (OAMJMS); 27-32 Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Open Access Macedonian Journal of Medical Sciences, Vol 5, Iss 1, Pp 27-32 (2017) Open Access Macedonian Journal of Medical Sciences; Vol 5, No 1 (2017): Feb 15 (OAMJMS); 27-32 |
| ISSN: | 1857-9655 |
| Popis: | AIM: To rule out maternal and pregnancy factors that may contribute to platelet count (PLT) changes in the first trimester of gestation and examine if there is any association between its levels and adverse perinatal outcome.METHODS: The study population included all patients from the first-trimester visit between 2013-2015 with pregnancy results. Linear multiple regression was constructed to rule out variables that may have a significant contribution to PLT. For each adverse outcome at birth, multiple logistic regression analysis was implemented to estimate the PLT effect.RESULTS: PLT was measured in 6092 patients. There was the significant contribution on PLT in the first trimester from maternal weight, the presence of rheumatologic disease, BHCG levels and MPV. There was a significant association between PLT and abnormal cardiotocography at delivery (OR 1.004; IC95% 1.001 to 1.007) and C-Section due to abnormal CTG (OR 1.005; IC95% 1.002 to 1.008). When adjusted for factors that interact with PLT there was also a significant association with pH at birth < 7.10 and gestational diabetes.CONCLUSIONS: Maternal and pregnancy factors can poorly predict relevant changes in PLT at the first trimester of gestation. PLT at first trimester of pregnancy might predict adverse perinatal outcome in combination with other markers. |
| Databáze: | OpenAIRE |
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