Differences detected in vivo between samples of aflatoxincontaminated peanut meal, following decontamination by two ammonia-based processes
| Autor: | G. E. Neal, M. J. Nagler, Laurentius Hoogenboom, P. Carthew, L. Weir, A. Verma, R. D. Coker, I. Latour, D. J. Judah |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Aflatoxin Arachis Health Toxicology and Mutagenesis Biological Availability Food Contamination Biology Kidney Weight Gain Toxicology Immunoenzyme Techniques Eating Ammonia chemistry.chemical_compound Aflatoxins In vivo Detoxification Animals Food science Mycotoxin Decontamination Wageningen Food Safety Research Liver Neoplasms digestive oral and skin physiology Public Health Environmental and Occupational Health food and beverages Organ Size General Chemistry Human decontamination Contamination Immunohistochemistry Rats Inbred F344 Rats Bioavailability Peanut Liver chemistry Biochemistry Chemistry (miscellaneous) Ammoniation Food Science |
| Zdroj: | Food Additives and Contaminants, 18(2), 137-149 Food Additives and Contaminants 18 (2001) 2 |
| ISSN: | 0265-203X |
| DOI: | 10.1080/02652030010011379 |
| Popis: | A sample of peanut meal, highly contaminated with aflatoxins, has been subjected to decontamination by two commercial ammonia-based processes. The original contaminated and the two decontaminated meals were fed to rats for 90 days. No lesions associated with aflatoxin-induced hepatocarcinogenesis were detected histologically following feeding with the two detoxified meals. There were, however, clear differences between the two meals in respect of growth rates of the rats. In addition, feeding one of the detoxified meals resulted in hepatic abnormalities detected using novel immunohistochemical reagents. Differences between the two detoxified meals were also indicated by the results of studies using meals 'spiked' with [14C]-aflatoxin B1 prior to being subjected to the detoxification processes. The meals differed in the bioavailability of the label. It was concluded that peanut meal where an initial, unacceptable level of contamination with aflatoxins had been reduced by two ammonia-based processes to comparable, acceptable levels, may still have different effects in vivo when incorporated into animal diets. |
| Databáze: | OpenAIRE |
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