Genetic variation of long non-coding RNA TINCR contribute to the susceptibility and progression of colorectal cancer
| Autor: | Shilun Tong, Wenhong Deng, Yu Ding, Dan Song, Yongbin Zheng, Kuang Xiao, Chao Yang |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Colorectal cancer colorectal cancer Single-nucleotide polymorphism Bioinformatics Polymorphism Single Nucleotide TINCR 03 medical and health sciences lncRNA 0302 clinical medicine Internal medicine Genetic variation medicine Humans SNP Genetic Predisposition to Disease Neoplasm Metastasis Allele Alleles Genetic Association Studies Aged Neoplasm Staging business.industry Case-control study Genetic Variation Middle Aged medicine.disease Long non-coding RNA 030104 developmental biology Tumor progression Case-Control Studies 030220 oncology & carcinogenesis Disease Progression Female RNA Long Noncoding variation genetic Colorectal Neoplasms business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.16538 |
| Popis: | // Yongbin Zheng 1 , Chao Yang 1 , Shilun Tong 1 , Yu Ding 1 , Wenhong Deng 1 , Dan Song 1 , Kuang Xiao 1 1 Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, PR China Correspondence to: Yongbin Zheng, email: zhengyongbinhb@163.com Keywords: colorectal cancer, variation, genetic, TINCR, lncRNA Received: January 05, 2017 Accepted: February 13, 2017 Published: March 24, 2017 ABSTRACT Colorectal cancer (CRC) accounts for the leading causes of cancer-related morbidity and mortality. However, a large part of heritable factors are warranted to be explored. Long non-coding RNAs (lncRNAs) serve critical roles in cancer development and progression. Herein, we explored effect of genetic variants of Tissue differentiation-inducing non-protein coding RNA (TINCR), a key lncRNA required for somatic tissue differentiation and tumor progression, on risk and progression of CRC. Three tagSNPs, including rs2288947, rs8105637, and rs12610531, were evaluated in in a two-stage, case-control study. Two SNPs, rs2288947 and rs8105637, were significantly associated with susceptibility of CRC in both stages. When pooled together, the allele G was significantly associated with 23% decreased risk of CRC (OR=0.77; 95% CI=0.67-0.88; P value = 1.2×10 -4 )for SNP rs2288947. While for SNP rs8105637, the allele A was significantly associated with 22% increased risk of CRC (OR=1.22; 95% CI=1.09-1.37; P value = 6.2×10 -4 ). The two SNPs were also statistically associated with occurrence of lymph node metastasis of CRC. The carriers of allele G are less likely to get lymph node metastasis (OR=0.77; 95% CI=0.63-0.94; P value = 0.011) for rs2288947, and the carriers of allele A are more likely to get lymph node metastasis (OR=1.22; 95% CI=1.03-1.43; P value = 0.019) for rs8105637. These results suggest that lncRNA TINCR polymorphisms may be implicated in the development and progression of CRC. |
| Databáze: | OpenAIRE |
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