The effect of cis- and trans-clomiphene citrate on the collagen content of fetal bone
| Autor: | Linda D. Marshall, Raja W. Abdul-Karim, John A. Souma |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
medicine.medical_specialty
Enclomiphene Placenta medicine.medical_treatment Toxicology Bone and Bones Clomiphene Structure-Activity Relationship Fetus Dry weight Pregnancy Internal medicine medicine Animals Citrates Femur Hysterotomy Pharmacology Treated group Chemistry Body Weight Abnormalities Drug-Induced Stereoisomerism Organ Size Fetal weight Fertility Endocrinology Gestation Female Collagen Rabbits |
| Zdroj: | Toxicology and Applied Pharmacology. 23:339-343 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(72)90195-0 |
| Popis: | cis- and trans-Clomiphene citrate were administered im to pregnant rabbits from day 21 to day 26 of gestation. Seven rabbits received 15 mg/kg and 6 rabbits 25 mg/kg of the cis-isomer daily. trans-Clomiphene citrate was given to 4 rabbits in a daily dose of 10 mg/kg and to 8 rabbits in a dose of 15 mg/kg; 8 rabbits served as controls. The rabbits were delivered by hysterotomy on day 27, and the fetuses and placentas were weighed. The femurs from liveborns were dissected free of soft tissue, and the wet and fat-free dry weights were recorded. The collagen and total ash of the femurs were determined. The only significant differences between the control and experimental rabbits occurred when trans-clomiphene 15 mg/kg was used. With this dose of trans-clomiphene, fetal weight was decreased from 25.5 ± 2.3 g to 20.2 ± 5.2 g (p = 0.02) and the collagen to dry weight ratio of bone from 18.6 ± 2.0 to 13.9 ± 2.9 (p < 0.01). The collagen to ash ratio in the trans-clomiphene 15 mg/kg treated group was 0.32 ± 0.07 compared to 0.5 ± 0.09 in the controls (p < 0.005). It is suggested that the changes in fetal weight and bone composition under the influence of the trans-isomer are due to its estrogenic properties. |
| Databáze: | OpenAIRE |
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