Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction
| Autor: | Sigurdur Boðvarsson, Maria Sasvari-Szekely, Zsolt Ronai, G.J. Arason, George Füst, Perla Thorbjornsdottir, Ragnhildur Kolka, Zoltán Prohászka, Sigurður Thór Sigurðarson, G. Thorgeirsson, Margit Kovács, Garðar Sigurðsson, Bernadett Blaskó |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Immunology Population Gene Dosage Iceland Myocardial Infarction chemical and pharmacologic phenomena Single-nucleotide polymorphism Biology Bioinformatics Polymerase Chain Reaction Polymorphism Single Nucleotide Gene dosage Risk Factors Genotype Complement C4b Humans Immunology and Allergy Genetic Predisposition to Disease Copy-number variation Risk factor Allele education Lymphotoxin-alpha Aged Aged 80 and over education.field_of_study Smoking C4A General Medicine Survival Analysis Female |
| Zdroj: | International Immunology. 20:31-37 |
| ISSN: | 1460-2377 0953-8178 |
| Popis: | Background and Objectives: Some recent data indicate that risk of death after acute coronary syndrome is under genetic control. Previously, we found that the C4B*Q0 genotype (low copy number of the C4B gene that encodes the fourth component of complement) is strongly associated with morbidity and mortality of cardiovascular diseases (CVD). The 1252 G allele of the lymphotoxin-alpha (LTA) gene encoded close to the C4B gene was also reported to be related to CVD-related mortality in an Oriental population. Methods: The relationship between the copy number of the genes encoding the fourth component of complement (C4A and C4B) and LTA 252 single-nucleotide polymorphism (SNP) on the one hand and mortality after acute myocardial infarction (AMI) was studied in 142 Icelandic patients. The number of the C4A and C4B genes was determined in genomic DNA samples by a newly developed real-time PCR-based method; lymphotoxin-alpha (LTA) 1252 A>G polymorphism was determined by PCR–restriction fragment length polymorphism analysis. Results: The C4B*Q0 genotype was found to be strongly associated with 1-year mortality, with a hazard ratio of 3.50 (1.38–8.87) (P 5 0.008) (adjusted Cox regression analysis). This association was, however, restricted to ever-smoking patients. By contrast, neither C4A gene copy numbers nor LTA 252 SNP did confer increased risk of mortality after AMI. Conclusions: This observation indicates that low C4B copy number is a strong risk factor for short-term mortality after AMI in smoking Icelandic patients, whereas LTA 252 G allele is not a risk factor in Caucasian population. |
| Databáze: | OpenAIRE |
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