The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice
| Autor: | Rebecca De Smet, Griet Conickx, Karlijn Debusschere, Smitha Kumar, Martine De Vos, Guy Joos, Debby Laukens, Stephanie Verschuere, Tania Maes, Guy Brusselle, Ken R. Bracke, Liesbeth Allais, Dirk Elewaut, Claude Cuvelier |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
TOBACCO-SMOKE
EXTRAINTESTINAL MANIFESTATIONS medicine.medical_treatment lcsh:Medicine Arthritis Inflammation Inflammatory bowel disease Feces Mice Lipocalin-2 medicine IMMUNE-RESPONSE Animals BOWEL-DISEASE lcsh:Science INDUCED PULMONARY INFLAMMATION TUMOR-NECROSIS-FACTOR Sequence Deletion Oncogene Proteins Multidisciplinary Lung business.industry Tumor Necrosis Factor-alpha lcsh:R Smoking Acute-phase protein Biology and Life Sciences FACTOR-ALPHA Pneumonia SPONDYLOARTHRITIS medicine.disease Inflammatory Bowel Diseases Lipocalins RHEUMATOID-ARTHRITIS Disease Models Animal Cytokine medicine.anatomical_structure Rheumatoid arthritis Immunology CYTOKINE MESSENGER-RNA Cytokines lcsh:Q Tumor necrosis factor alpha medicine.symptom business Research Article Acute-Phase Proteins |
| Zdroj: | PLoS ONE PLOS ONE PLoS ONE, Vol 10, Iss 11, p e0141570 (2015) |
| ISSN: | 1932-6203 |
| Popis: | The inflammatory cytokine TNF-alpha is a central mediator in many immune-mediated diseases, such as Crohn's disease (CD), spondyloarthritis (SpA) and chronic obstructive pulmonary disease (COPD). Epidemiologic studies have shown that cigarette smoking (CS) is a prominent common risk factor in these TNF-dependent diseases. We exposed TNF Delta ARE mice; in which a systemic TNF-alpha overexpression leads to the development of inflammation; to 2 or 4 weeks of air or CS. We investigated the effect of deregulated TNF expression on CS-induced pulmonary inflammation and the effect of CS exposure on the initiation and progression of gut and joint inflammation. Upon 2 weeks of CS exposure, inflammation in lungs of TNF Delta ARE mice was significantly aggravated. However, upon 4 weeks of CS-exposure, this aggravation was no longer observed. TNF Delta ARE mice have no increases in CD4+ and CD8+ T cells and a diminished neutrophil response in the lungs after 4 weeks of CS exposure. In the gut and joints of TNF Delta ARE mice, 2 or 4 weeks of CS exposure did not modulate the development of inflammation. In conclusion, CS exposure does not modulate gut and joint inflammation in TNF Delta ARE mice. The lung responses towards CS in TNF Delta ARE mice however depend on the duration of CS exposure. |
| Databáze: | OpenAIRE |
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