Stereological estimation of the total number of neurons in the murine hippocampus using the optical disector
| Autor: | Paul Stanford, Jing Hua Zhao, Ian P. Everall, Daniel Mackay, Iman Abusaad, David A. Collier |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Hippocampus Stereology Cell Count Biology Hippocampal formation Mice Inbred strain Species Specificity Internal medicine medicine Animals Neurons Mice Inbred NZB General Neuroscience Dentate gyrus Pyramidal Cells Anatomy Granule cell Mice Inbred C57BL medicine.anatomical_structure Endocrinology Mice Inbred DBA Female Neuron Pyramidal cell Algorithms |
| Zdroj: | The Journal of comparative neurology. 408(4) |
| ISSN: | 0021-9967 |
| Popis: | Using a stereological method, the optical disector, we examined three inbred strains of mice (NZB/BINJ, DBA/2, and C57BL/6J) for morphological differences in volume, neuronal number, and density of the pyramidal cell and dentate gyrus granule cell layers of the hippocampus. We found significant differences in volume and neuronal number for both regions between the three strains at 9 weeks of age, but only modest differences in neuronal density. The left dentate volume was 90% larger in the NZB strain and 70% greater in the DBA strain (P |
| Databáze: | OpenAIRE |
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