The role of probiotics and postbiotics in modulating the gut microbiome-immune system axis in the pediatric age
| Autor: | Veronica Giglio, Laura Carucci, Roberto Berni Canani, Serena Coppola, Jon A. Vanderhoof, Anna Luzzetti |
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| Přispěvatelé: | Carucci, Laura, Coppola, Serena, Luzzetti, Anna, Giglio, Veronica, Vanderhoof, Jon, Berni Canani, Roberto |
| Rok vydání: | 2021 |
| Předmět: |
Immunity
mucosal Adaptive Immunity Bioinformatics Human health Immune system Homeostasi Humans Medicine Therapeutic strategy business.industry Probiotics Infant Newborn Infant Pediatric age Acquired immune system Immunity Innate Gut microbiome Gastrointestinal Microbiome Prebiotics Child Preschool Immune System Pediatrics Perinatology and Child Health Dysbiosis Gene-Environment Interaction business |
| Zdroj: | Minerva Pediatrics. 73 |
| ISSN: | 2724-5780 2724-5276 |
| DOI: | 10.23736/s2724-5276.21.06188-0 |
| Popis: | The complex microbial community of the gut microbiome plays a fundamental role in driving development and function of the human immune system. This phenomenon is named the gut microbiome-immune system axis. When operating optimally, this axis influences both innate and adaptive immunity, which orchestrates the maintenance of crucial elements of host-microorganisms symbiosis, in a dialogue that modulates responses in the most beneficial way. Growing evidence reveals some environmental factors which can positively and negatively modulate the gut microbiome-immune system axis with consequences on the body health status. Several conditions which increasingly affect the pediatric age, such as allergies, autoimmune and inflammatory disorders, arise from a failure of the gut microbiome-immune system axis. Prenatal or postnatal modulation of this axis through some interventional strategies (including diet, probiotics and postbiotics), may lead to a positive gene-environment interaction with improvement of immune-modulatory effects and final positive effect on human health. In particular probiotics and postbiotics exerting pleiotropic regulatory actions on the gut-microbiome-immune system axis provide an innovative preventive and therapeutic strategy for many pediatric conditions. |
| Databáze: | OpenAIRE |
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