Inhibitory effects of azelastine on nasal allergic responses in sensitized guinea pigs
| Autor: | Kohji Asakura, Shinya Sohma, Hideaki Shirasaki, Akikatsu Kataura |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Nasal cavity Rhinitis Allergic Perennial Ovalbumin Guinea Pigs Vascular permeability Histamine Release Capillary Permeability chemistry.chemical_compound Antigen In vivo otorhinolaryngologic diseases Animals Medicine Leukotriene C4 business.industry General Medicine respiratory system Azelastine medicine.anatomical_structure Otorhinolaryngology chemistry Immunology Histamine H1 Antagonists Phthalazines Immunization SRS-A Nasal Lavage Fluid business Histamine medicine.drug |
| Zdroj: | European Archives of Oto-Rhino-Laryngology. 249:279-282 |
| ISSN: | 1434-4726 0937-4477 |
| DOI: | 10.1007/bf00714493 |
| Popis: | The in vivo effects of the antiallergic drug azelastine were investigated in sensitized guinea pigs. Topical administration of antigen into the nasal cavity produced an increase in nasal vascular permeability together with an increase in both the histamine and leukotriene C4 (LTC4) concentrations of nasal lavage fluid. Pre-treatment with azelastine significantly inhibited both the LTC4 release and the increase in nasal vascular permeability. These results suggest that azelastine inhibits the release of antigen-induced leukotrienes and increases nasal vascular permeability in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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