Insulin with Chondroitinase ABC Treats the Rat Model of Acute Spinal Cord Injury
| Autor: | Dianming Jiang, Zhengxue Quan, Yunsheng Ou, Yang Yg |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Programmed cell death medicine.medical_specialty Combination therapy Traumatic brain injury medicine.medical_treatment Neural Conduction Apoptosis Chondroitin ABC Lyase Motor Activity Pharmacology Biochemistry Rats Sprague-Dawley GAP-43 Protein medicine Animals Hypoglycemic Agents Insulin Gap-43 protein Evoked Potentials Spinal Cord Injuries Cell Proliferation biology Electromyography Cell growth business.industry fungi Biochemistry (medical) Therapeutic effect Recovery of Function Cell Biology General Medicine medicine.disease Axons Rats Surgery Disease Models Animal Acute Disease biology.protein Drug Therapy Combination Female business |
| Zdroj: | Journal of International Medical Research. 37:1097-1107 |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | Traumatic brain injury is often associated with acute spinal cord injury (ASCI). Insulin and chondroitinase ABC (ChABC) are both therapeutically effective, but the combined therapeutic effect of insulin and ChABC is still not clear. A combination of insulin and ChABC were used to treat a rat model of ASCI. This combination therapy prevented neuronal cell death by improving motor function, increasing cell growth and inhibiting cell apoptosis in ASCI rats. Expression of growth-associated protein 43, a marker of axonal re-growth, increased after combined treatment with insulin and ChABC. These results may provide a basis for a future method of treating ASCI. |
| Databáze: | OpenAIRE |
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