Effect of aprotinin on activated clotting time whole blood and plasma heparin measurements
| Autor: | Demetrios G. Lappas, Samuel A. Santoro, Anastasios N. Triantafillou, Alexander Alsoufiev, J. Heinrich Joist, Lawrence T. Goodnough, George J. Despotis, Diane Joiner-Maier |
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| Rok vydání: | 1995 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Whole Blood Coagulation Time Activated clotting time law.invention Plasma Aprotinin law Internal medicine Cardiopulmonary bypass medicine Humans Kaolin Whole blood Cardiopulmonary Bypass medicine.diagnostic_test biology Heparin business.industry Diatomaceous Earth Protamine Endocrinology Clotting time Enzyme inhibitor Anesthesia biology.protein Surgery Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The Annals of Thoracic Surgery. 59:106-111 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/0003-4975(94)00798-c |
| Popis: | Twenty cardiac surgical patients requiring cardiopulmonary bypass were enrolled in this study designed to evaluate the effect of aprotinin on activated clotting time (kaolin and celite), whole blood, and laboratory-based plasma (anti-Xa) heparin measurements. Whole blood heparin measurements were not different ( p = 0.98) between aprotinin-treated (3.2 ± 2.8 U/mL) and control (3.2 ± 3.0 U/mL) specimens. Plasma anti-Xa heparin measurements were also not different ( p = 0.95) between aprotinin-treated (2.7 ± 2.5 U/mL) and control (2.8 ± 2.5 U/mL) specimens. The relationship between whole blood (plasma equivalent) and plasma heparin measurements was similar ( p 0 = 0.1) in the presence (slope, 1.04; r 2 =0.89) or absence (slope, 1.11; r 2 = 0.89) of aprotinin. In contrast to weak correlations between celite ( r = 0.50) or kaolin ( r = 0.53) activated clotting time values, whole blood heparin measurements correlated well ( r = 0.93) with plasma heparin measurements during cardiopulmonary bypass in the presence of aprotinin. These findings indicate that whole blood heparin measurements are unaffected by aprotinin and correlate well with plasma anti-Xa heparin measurements even in the presence of aprotinin. Therefore, the automated protamine titration assay can be used to monitor accurately heparin concentrations in patients receiving aprotinin. |
| Databáze: | OpenAIRE |
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