Mathematical and deep learning analysis based on tissue dielectric properties at low frequencies predict outcome in human breast cancer

Autor:	Mohammed Nader Salama, Mohamed Moustafa Azmy, Mamdouh M. Shawki, Sanaa Shawki
Rok vydání:	2022
Předmět:	Permittivity 030310 physiology Biomedical Engineering Biophysics Breast Neoplasms Health Informatics Bioengineering Dielectric Electric Capacitance Capacitance Biomaterials 03 medical and health sciences Deep Learning 0302 clinical medicine Breast cancer medicine Range (statistics) Humans Physics 0303 health sciences Artificial neural network Electric Conductivity Cancer Prognosis medicine.disease Support vector machine 030220 oncology & carcinogenesis Female Information Systems Biomedical engineering
Zdroj:	Technology and Health Care. 30:633-645
ISSN:	1878-7401 0928-7329
DOI:	10.3233/thc-213096
Popis:	BACKGROUND: The early detection of human breast cancer represents a great chance of survival. Malignant tissues have more water content and higher electrolytes concentration while they have lower fat content than the normal. These cancer biochemical characters provide malignant tissue with high electric permittivity (ε´) and conductivity (σ). OBJECTIVE: To examine if the dielectric behavior of normal and malignant tissues at low frequencies (α dispersion) will lead to the threshold (separating) line between them and find the threshold values of capacitance and resistance. These data are used as input for deep learning neural networks, and the outcomes are normal or malignant. METHODS: ε´ and σ in the range of 50 Hz to 100 KHz for 15 human malignant tissues and their corresponding normal ones have been measured. The separating line equation between the two classes is found by mathematical calculations and verified via support vector machine (SVM). Normal range and the threshold value of both normal capacitance and resistance are calculated. RESULTS: Deep learning analysis has an accuracy of 91.7%, 85.7% sensitivity, and 100% specificity for instant and automatic prediction of the type of breast tissue, either normal or malignant. CONCLUSIONS: These data can be used in both cancer diagnosis and prognosis follow-up.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2279616371c428d72dd6af73fc224ef https://doi.org/10.3233/thc-213096 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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