The Prospects of the Two-Day Cardiopulmonary Exercise Test (CPET) in ME/CFS Patients: A Meta-Analysis
| Autor: | Eun-Su Jang, Eun-Jin Lim, Eun-Bum Kang, Chang-Gue Son |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty lcsh:Medicine Review chronic fatigue syndrome Objective assessment 03 medical and health sciences 0302 clinical medicine Internal medicine Cardiopulmonary exercise test medicine Chronic fatigue syndrome Depression (differential diagnoses) 030304 developmental biology 0303 health sciences business.industry lcsh:R General Medicine medicine.disease Clinical trial myalgic encephalomyelitis Postexertional malaise Meta-analysis postexertional malaise Cardiology Ventilatory threshold business 030217 neurology & neurosurgery cardiopulmonary exercise test |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 4040, p 4040 (2020) Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Popis: | Background: The diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is problematic due to the lack of established objective measurements. Postexertional malaise (PEM) is a hallmark of ME/CFS, and the two-day cardiopulmonary exercise test (CPET) has been tested as a tool to assess functional impairment in ME/CFS patients. This study aimed to estimate the potential of the CPET. Methods: We reviewed studies of the two-day CPET and meta-analyzed the differences between ME/CFS patients and controls regarding four parameters: volume of oxygen consumption and level of workload at peak (VO2peak, Workloadpeak) and at ventilatory threshold (VO2@VT, Workload@VT). Results: The overall mean values of all parameters were lower on the 2nd day of the CPET than the 1st in ME/CFS patients, while it increased in the controls. From the meta-analysis, the difference between patients and controls was highly significant at Workload@VT (overall mean: −10.8 at Test 1 vs. −33.0 at Test 2, p < 0.05), which may reflect present the functional impairment associated with PEM. Conclusions: Our results show the potential of the two-day CPET to serve as an objective assessment of PEM in ME/CFS patients. Further clinical trials are required to validate this tool compared to other fatigue-inducing disorders, including depression, using well-designed large-scale studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|