Comparative study of the CCF-like pattern recognition protein in different Lumbricid species
| Autor: | Marcela Šilerová, Radka Josková, Petra Procházková, Guy Josens, Martin Bilej, Patrick De Baetselier, Alain Beschin |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Eisenia fetida
Immunology Molecular Sequence Data Disaccharides Substrate Specificity Aporrectodea caliginosa Cell Line Tumor Lectins Animals Humans Amino Acid Sequence Oligochaeta Phylogeny Enzyme Precursors Innate immune system biology Base Sequence Aporrectodea longa business.industry Cytotoxins Pattern recognition Prophenoloxidase biology.organism_classification Lumbricus rubellus Random Amplified Polymorphic DNA Technique Artificial intelligence Aporrectodea rosea business Sequence Alignment Lumbricus terrestris Catechol Oxidase Developmental Biology |
| Zdroj: | Developmental and comparative immunology. 30(9) |
| ISSN: | 0145-305X |
| Popis: | Coelomic fluid of the Lumbricid Eisenia fetida contains a 42-kDa pattern recognition protein named coelomic cytolytic factor (CCF) that binds microbial cell wall components and triggers the activation of the prophenoloxidase cascade, an important invertebrate defense pathway. Here we report on the sequence characterization of CCF-like molecules of other Lumbricids: Aporrectodea caliginosa, Aporrectodea icterica, Aporrectodea longa, Aporrectodea rosea, Dendrobaena veneta, Lumbricus rubellus and Lumbricus terrestris, and show that CCF from E. fetida has a broader saccharide-binding specificity, being the only one recognizing N,N'-diacetylchitobiose. We suggest that the broad recognition repertoire of E. fetida CCF reflects a particular microbial environment this species lives in. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect