Electrosprayed chitosan microcapsules as delivery vehicles for vaginal phytoformulations
| Autor: | Jorge Esteban Sayago, Iris Catiana Zampini, Myriam Arias, Amparo López-Rubio, Guillermo Schmeda-Hirschmann, Laura G. Gómez-Mascaraque, María Inés Isla, Liudis Leidy Pino Ramos, María Alejandra Moreno |
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| Přispěvatelé: | Universidad Nacional de Tucumán, Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina), Agencia Nacional de Promoción Científica y Tecnológica (Argentina), Universidad de Talca, Consejo Superior de Investigaciones Científicas (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Vaginal tablets Antifungal Agents Antioxidant Polymers and Plastics medicine.medical_treatment Capsules Saccharomyces cerevisiae 02 engineering and technology Ciencias Biológicas purl.org/becyt/ford/1 [https] Chitosan 03 medical and health sciences chemistry.chemical_compound Anti-Candida Materials Chemistry medicine Humans Solubility purl.org/becyt/ford/1.6 [https] Medicinal plants Candida Larrea divaricata Drug Carriers Plants Medicinal Chromatography Plant Extracts Organic Chemistry Argentinean dry plant extracts 021001 nanoscience & nanotechnology Antimicrobial Bioavailability Administration Intravaginal Microcapsules 030104 developmental biology chemistry Otros Tópicos Biológicos Female 0210 nano-technology Drug carrier CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | The design of novel delivery systems to treat vaginal fungal infections is a topic of high interest. Chitosan, being itself antimicrobial and having good mucoadhesive properties, is an excellent candidate as a delivery matrix for active compounds. In this work, chitosan microcapsules containing dry extracts of Argentinean medicinal plants with proved biological properties (Larrea divaricata, L. cuneifolia, L. nitida, Zuccagnia punctata and Tetraglochin andina) were developed through electrospraying and compared with conventionally used tablets containing the same extracts. Total phenolics, loading efficacy, physical properties, morphology and particle size, molecular organization, water sorption capacity, release of bioactive compounds and biological properties were assessed. The encapsulation process or the inclusion in tablets did not degrade the bioactive compounds of the extracts. The release of phenolic compounds from chitosan microcapsules was faster than from tablets. The fingerprint of released phenolic compounds from microcapsules and tablets was similar to that from the dry extracts and the antioxidant and antifungal capacity remained unchanged. The FT-IR analysis suggested interactions between the chitosan and the extracts, which explained why the microcapsules kept the integrity in slightly acidic media. Increased solubility of the extracts when incorporated in the microcapsules was seen in simulated vaginal fluid, potentially increasing the bioavailability of bioactive compounds in the vaginal environment. This research was supported by grants from Secretaría de Ciencia, Arte e Innovación Tecnológica de la Universidad Nacional de Tucumán, Argentina (SCAIT-UNT), Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina (CONICET), Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT), Universidad de Talca, Chile (PIEI-QUIM-BIO) and EMHE-CSIC (Grant MHE-200038). L. G. Gómez-Mascaraque, is recipient of a predoctoral contract (BES-2013-065883) from the Spanish Ministry of Economy, Industry and Competitiveness (MINECO). The authors thank the Central Support Service for Experimental Research (SCSIE) of the University of Valencia for the electronic microscopy service. |
| Databáze: | OpenAIRE |
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