Effects of continuous theta burst transcranial magnetic stimulation on cortical excitability in patients with idiopathic generalized epilepsy
Autor: | Erdal Eroglu, Semai Bek, Güray Koç, Zeki Odabasi, Zeki Gökçil, Tayfun Kasikci |
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Přispěvatelé: | TOBB ETU, Faculty of Medicine, Department of Internal Medical Sciences, TOBB ETÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Eroğlu, Erdal |
Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine Adolescent medicine.medical_treatment CTBS Stimulation Idiopathic generalized epilepsy Young Adult 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Cerebellum Humans Medicine Evoked potential business.industry Motor Cortex Cortical excitability Evoked Potentials Motor medicine.disease Transcranial Magnetic Stimulation Transcranial magnetic stimulation Transcranial magnetic stimulatio 030104 developmental biology medicine.anatomical_structure Neurology Continuous theta burst stimulation Epilepsy Generalized Female Silent period Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery Motor cortex |
Zdroj: | Epilepsy & Behavior. 77:26-29 |
ISSN: | 1525-5050 |
DOI: | 10.1016/j.yebeh.2017.09.011 |
Popis: | Introduction Transcranial magnetic stimulation (TMS) is a noninvasive technique for investigating cortical physiologic functions in the brain. In this study, the effects of continuous theta burst stimulation (cTBS) on motor evoked potential (MEP) parameters in patients with idiopathic generalized epilepsy (IGE) were investigated. Materials and methods Fifteen patients with IGE were included. Motor threshold (MT) and cortical silent period (CSP) were determined before cTBS application. Next, cTBS was applied to the dominant (left) hemisphere M1 hand area as the first application. After 1 day, cTBS was applied first to the left M1 hand area and then to the right lateral cerebellar area as the second application. Parameters were again determined after the applications. Results There was no difference in resting MT values before and after cTBS application (p > 0.05). Although CSP increased after stimulation (p < 0.05), it was not significantly different between applications (p > 0.05). Conclusion For patients with epilepsy, cTBS is a safe technique when applied at a low intensity. The inhibitory effect of cTBS, a noninvasive technique, on cortical excitability in patients with IGE was determined using MEP parameters. The effect lasted at least 1 h. To our knowledge, this is the first study to assess the effect of cTBS on cortical excitability in patients with IGE. Our findings indicate that cTBS decreases cortical excitability in patients with IGE. |
Databáze: | OpenAIRE |
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