Cartilage tissue engineering: From biomaterials and stem cells to osteoarthritis treatments

Autor: Claire Vinatier, Jérôme Guicheux
Přispěvatelé: Regenerative Medicine and Skeleton (RMeS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS), Université de Nantes - UFR Odontologie, Université de Nantes (UN), UMR791, Laboratoire d’Ingénierie Ostéo-Articulaire et Dentaire, OTONN PHU4 CHU de Nantes, Institut National de la Santé et de la Recherche Médicale (INSERM), This work was funded by the ‘‘Fondation arthritis’’ through its network program Research on osteoarthritis diseases (ROAD) and from the Pays de la Loire region in France through its program Longevité mobilité autonomie (LMA)., Vinatier, Claire
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Cartilage
Articular
Scaffold
medicine.medical_specialty
Pathology
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Connective tissue
Biocompatible Materials
Osteoarthritis
Stem cells
MESH: Stem Cells
MESH: Tissue Engineering
Cartilage tissue engineering
Biomaterials
03 medical and health sciences
Tissue engineering
MESH: Biocompatible Materials
MESH: Osteoarthritis
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Medicine
Humans
Orthopedics and Sports Medicine
Process (anatomy)
Stem cell transplantation for articular cartilage repair
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
[SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
MESH: Humans
Tissue Engineering
business.industry
Cartilage
Rehabilitation
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
medicine.disease
Surgery
030104 developmental biology
medicine.anatomical_structure
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
MESH: Cartilage
Articular
Stem cell
business
Zdroj: Annals of Physical and Rehabilitation Medicine
Annals of Physical and Rehabilitation Medicine, Elsevier Masson, 2016, 59 (3), pp.139-44. ⟨10.1016/j.rehab.2016.03.002⟩
ISSN: 1877-0657
DOI: 10.1016/j.rehab.2016.03.002⟩
Popis: International audience; Articular cartilage is a non-vascularized and poorly cellularized connective tissue that is frequently damaged as a result of trauma and degenerative joint diseases such as osteoarthrtis. Because of the absence of vascularization, articular cartilage has low capacity for spontaneous repair. Today, and despite a large number of preclinical data, no therapy capable of restoring the healthy structure and function of damaged articular cartilage is clinically available. Tissue-engineering strategies involving the combination of cells, scaffolding biomaterials and bioactive agents have been of interest notably for the repair of damaged articular cartilage. During the last 30 years, cartilage tissue engineering has evolved from the treatment of focal lesions of articular cartilage to the development of strategies targeting the osteoarthritis process. In this review, we focus on the different aspects of tissue engineering applied to cartilage engineering. We first discuss cells, biomaterials and biological or environmental factors instrumental to the development of cartilage tissue engineering, then review the potential development of cartilage engineering strategies targeting new emerging pathogenic mechanisms of osteoarthritis.
Databáze: OpenAIRE
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