Involvement of the dopaminergic system in the reward-related behavior of pregabalin

Autor:	Ahmed Gaber, Turki Alkhalifa, Fahad S. Alshehri, Zahoor A. Shah, Amal A. Alghorabi, Ahmad Almalki, Ana Maria Trindade Grégio Hardy, Aliyah M. Marghalani, Yusuf S. Althobaiti, Farooq M. Almutairi, Hashem O. Alsaab, Alqassem Y. Hakami, Ebtehal Altowairqi, Atiah H. Almalki, Walaa F. Alsanie
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Male 0301 basic medicine medicine.drug_class media_common.quotation_subject medicine.medical_treatment Science Pregabalin Pharmacology Neurotransmission Article Random Allocation 03 medical and health sciences 0302 clinical medicine Reward medicine Animals Saline media_common Mice Inbred BALB C Multidisciplinary Behavior Animal business.industry Dopaminergic Neurons Receptors Dopamine D1 Addiction Dopaminergic Glutamate receptor Receptor antagonist Conditioned place preference 030104 developmental biology Anti-Anxiety Agents Medicine 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine business 030217 neurology & neurosurgery Neuroscience medicine.drug
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports
ISSN:	2045-2322
Popis:	There has been an increase in cases of drug addiction and prescription drug abuse worldwide. Recently, pregabalin abuse has been a focus for many healthcare agencies, as highlighted by epidemiological studies. We previously evaluated the possibility of pregabalin abuse using the conditioned place preference (CPP) paradigm. We observed that a 60 mg/kg dose could induce CPP in mice and that pregabalin-rewarding properties were mediated through glutamate neurotransmission. Notably, the dopaminergic reward circuitry is also known to play a crucial role in medication-seeking behavior. Therefore, this study aimed to explore the possible involvement of dopaminergic receptor-1 in pregabalin-induced CPP. Mice were randomly allocated to receive saline or the dopamine-1 receptor antagonist SKF-83566 (0.03 mg/kg, intraperitoneal). After 30 min, the mice received either saline or pregabalin (60 mg/kg) during the conditioning phase. Among the control groups that received saline or SKF-83566, the time spent in the two conditioning chambers was not significantly altered. However, among the pregabalin-treated group, there was a marked increase in the time spent in the drug-paired chamber compared to the time spent in the vehicle-paired chamber. Notably, blocking dopamine-1 receptors with SKF-83566 completely prevented pregabalin-induced place preference, thus demonstrating the engagement of the dopaminergic system in pregabalin-induced reward-related behavior.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a221002c3f605d1a85b1ea4beb8b523a https://doaj.org/article/3398dfba11a247c8abe43f67d64910f4 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.