Beneficial effects of an intradialytic cycling training program in patients with end-stage kidney disease

Autor: Bruno Pereira, Céline Coutard, Sophie Lemoine-Morel, Brice Martin, Myriam Rouchon-Isnard, Carole Groussard, Fanny Romain, Ludivine Malarde, Nathalie Boisseau
Přispěvatelé: Laboratoire Mouvement Sport Santé (M2S), École normale supérieure - Cachan (ENS Cachan)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ATMO Auvergne-Rhône-Alpes (ATMO-AURA), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), École normale supérieure - Cachan (ENS Cachan)-Université de Rennes (UR)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Rok vydání: 2015
Předmět:
Male
entraînement physique
Physiology
[SDV]Life Sciences [q-bio]
Endocrinology
Diabetes and Metabolism
Physical fitness
Pilot Projects
condition physique
medicine.disease_cause
Absorptiometry
Photon
oxidative stress
Aged
80 and over
Nutrition and Dietetics
medicine.diagnostic_test
néphropathie chronique
General Medicine
Middle Aged
Exercise Therapy
3. Good health
Lipoproteins
LDL
lipid profile
Body Composition
Female
Training program
Adult
medicine.medical_specialty
Young Adult
Physiology (medical)
Internal medicine
isoprostanes
medicine
Humans
In patient
End-stage kidney disease
Beneficial effects
Triglycerides
profil lipidique
Aged
Glutathione Peroxidase
Superoxide Dismutase
business.industry
Cholesterol
HDL
stress oxydatif
Cholesterol
LDL
medicine.disease
Bicycling
Exercise Test
physical fitness
Physical therapy
Kidney Failure
Chronic
Lipid Peroxidation
Lipid profile
business
exercise training
Biomarkers
chronic kidney disease
Oxidative stress
Kidney disease
Zdroj: Applied Physiology, Nutrition, and Metabolism
Applied Physiology, Nutrition, and Metabolism, NRC Research Press (Canadian Science Publishing), 2015, 8 (6), pp.1-7. ⟨10.1139/apnm-2014-0357⟩
Applied Physiology, Nutrition, and Metabolism, 2015, 8 (6), pp.1-7. ⟨10.1139/apnm-2014-0357⟩
ISSN: 1715-5320
1715-5312
DOI: 10.1139/apnm-2014-0357
Popis: In chronic kidney disease (CKD), oxidative stress (OS) plays a central role in the development of cardiovascular diseases. This pilot program aimed to determine whether an intradialytic aerobic cycling training protocol, by increasing physical fitness, could reduce OS and improve other CKD-related disorders such as altered body composition and lipid profile. Eighteen hemodialysis patients were randomly assigned to either an intradialytic training (cycling: 30 min, 55%–60% peak power, 3 days/week) group (EX; n = 8) or a control group (CON; n = 10) for 3 months. Body composition (from dual-energy X-ray absorptiometry), physical fitness (peak oxygen uptake and the 6-minute walk test (6MWT)), lipid profile (triglycerides (TG), total cholesterol, high-density lipoprotein, and low-density lipoprotein (LDL)), and pro/antioxidant status (15-F2α-isoprostanes (F2-IsoP) and oxidized LDL in plasma; superoxide dismutase, glutathione peroxidase, and reduced/oxidized glutathione in erythrocytes) were determined at baseline and 3 months later. The intradialytic training protocol did not modify body composition but had significant effects on physical fitness, lipid profile, and pro/antioxidant status. Indeed, at 3 months: (i) performance on the 6MWT was increased in EX (+23.4%, p < 0.001) but did not change in CON, (ii) plasma TG were reduced in EX (–23%, p < 0.03) but were not modified in CON, and (iii) plasma F2-IsoP concentrations were lower in EX than in CON (–35.7%, p = 0.02). In conclusion, our results show that 30 min of intradialytic training, 3 times per week for 3 months, are enough to exert beneficial effects on the most sensitive and reliable marker of lipid peroxidation (IsoP) while improving CKD-associated disorders (lipid profile and physical fitness). Intradialytic aerobic cycling training represents a useful and easy strategy to reduce CKD-associated disorders. These results need to be confirmed with a larger randomized study.
Databáze: OpenAIRE
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