Prenylflavonoids from fruit of Macaranga tanarius promote glucose uptake via AMPK activation in L6 myotubes
Autor: | Yukiko Saito, Je-Tae Woo, Noriyuki Natsume, Takayuki Yonezawa, Toshiaki Teruya |
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Rok vydání: | 2021 |
Předmět: |
Naringenin
Glucose uptake Muscle Fibers Skeletal AMP-Activated Protein Kinases Carbohydrate metabolism Pharmacology 01 natural sciences Macaranga tanarius Phosphatidylinositol 3-Kinases chemistry.chemical_compound Insulin Glucose homeostasis Phosphorylation Muscle Skeletal Glucose Transporter Type 4 biology 010405 organic chemistry Chemistry Euphorbiaceae food and beverages AMPK biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Glucose Fruit biology.protein Molecular Medicine GLUT1 Glucose Transporter Type 1 |
Zdroj: | Journal of Natural Medicines. 75:813-823 |
ISSN: | 1861-0293 1340-3443 |
Popis: | Skeletal muscle is a major tissue of glucose consumption and plays an important role in glucose homeostasis. Prenylflavonoids, a component of Macaranga tanarius fruits, have been reported to have antioxidant, antibacterial, and anticancer effects. However, the effects of these compounds on skeletal muscle glucose metabolism are unclear. Here, we isolated five prenylflavonoids from M. tanarius fruits, and investigated the mechanism of action of these compounds on skeletal muscle cells using L6 myotubes. We found that isonymphaeol B and 3'-geranyl naringenin increased glucose uptake in a dose-dependent manner. Furthermore, both isonymphaeol B and 3'-geranyl naringenin increased AMPK phosphorylation but did not affect PI3K-Akt phosphorylation. Isonymphaeol B and 3'-geranyl naringenin also increased Glut1 mRNA expression and plasma membrane GLUT1 protein levels. These results suggest that isonymphaeol B and 3'-geranyl naringenin have beneficial effects on glucose metabolism through AMPK and GLUT1 pathway. Isonymphaeol B and 3'-geranyl naringenin may be potential lead candidates for antidiabetic drug development. |
Databáze: | OpenAIRE |
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