Platelet aggregation and recruitment with aspirin-clopidogrel therapy
| Autor: | Larry D. Brace, John F. Cursio, Cathy M. Helgason, Enzo Grossi, Dilip K. Pandey, Aziz Valika |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Ticlopidine
Platelet aggregation Combination therapy Platelet Aggregation Pharmacology Brain Ischemia Platelet reactivity Cohort Studies medicine Humans Platelet cardiovascular diseases ASPIRIN RESISTANCE Aspirin business.industry Clopidogrel Stroke Thromboxane B2 Neurology Anesthesia Drug Therapy Combination Neurology (clinical) Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors circulatory and respiratory physiology medicine.drug |
| Zdroj: | Cerebrovascular diseases (Basel, Switzerland). 25(5) |
| ISSN: | 1421-9786 |
| Popis: | Background: Aspirin-clopidogrel combination therapy inhibits platelet aggregation. The effect on platelet recruitment is unknown. Methods: Thirty chronic ischemic stroke patients taking aspirin alone followed by aspirin-clopidogrel combined therapy had platelet reactivity tests performed over 3 months: ex vivo platelet aggregation, platelet recruitment and urinary 11-dehydro-thromboxane B2 (11-dhTxB2)excretion. Statistical analysis of variance compared platelet aggregation and recruitment between aspirin alone and aspirin-clopidogrel, and longitudinal regression analysis estimated platelet recruitment over time. Nonlinear mapping defined variable connections in each patient. Results: Statistically significant differences were found between aspirin alone and aspirin-clopidogrel for (1) adenosine-diphosphate- and collagen-induced platelet aggregation and maximum inhibition of platelet recruitment and (2) increasing inhibition of platelet recruitment over time. Urinary 11-dhTxB2 excretion did not predict platelet aggregation response. Nonlinear mapping showed patient-unique variable interconnections. Conclusions: Platelet inhibition with aspirin-clopidogrel may increase over time, and future studies should focus on this finding in the context of vascular complications. |
| Databáze: | OpenAIRE |
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