Pleomorphic CD8+ Small/Medium Size Cutaneous T-Cell Lymphoma
| Autor: | Ziad Khamaysi, R Epelbaum, Yehudith Ben-Arieh, Reuven Bergman |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Time Factors CD30 Proliferation index Biopsy CD8 Antigens T-Lymphocytes Dermatology Immunophenotyping Pathology and Forensic Medicine Immunoenzyme Techniques Dermis medicine Humans Mycosis fungoides business.industry Papillary dermis Cutaneous T-cell lymphoma General Medicine Gene rearrangement Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Lymphoma T-Cell Cutaneous Lymphoma Treatment Outcome medicine.anatomical_structure Female business Follow-Up Studies |
| Zdroj: | The American Journal of Dermatopathology. 28:434-437 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/01.dad.0000210389.36724.dd |
| Popis: | Pleomorphic small/medium-sized cutaneous T-cell lymphoma is a recently recognized rare type of cutaneous T-cell lymphoma which is clinicopathologically different from mycosis fungoides and Sezary syndrome. By definition the phenotype of the neoplastic lymphocytes in pleomorphic small/medium-sized cutaneous CD3CD4CD8 but CD8 pleomorphic small/medium sized cutaneous T-cell lymphoma cases have been occasionally described. We describe a 55-year-old female with a pruritic erythematous nodule on the lateral aspect of her right foot present for 1.5 years. Histology revealed a nonepidermotropic lichenoid infiltrate in the papillary dermis and a patchy infiltrate in the mid and lower dermis composed of small to medium-sized pleomorphic lymphocytes. The immunophenotype of these lymphocytes was CD3CD4CD8TIA-1. Staining for CD20, CD30, CD56, TdT, and LMP1 were negative, and the Ki-67 proliferation index was 5% to 10%. Gene rearrangement studies demonstrated a T-cell clone. The laboratory and imaging workup did not reveal extracutaneous involvement. The lesion was treated by local irradiation but a follow-up biopsy demonstrated only partial remission. Consequently, the lesion was treated by surgical excision. |
| Databáze: | OpenAIRE |
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