Correlation of long-term glycemic control as measured by glycated hemoglobin with serum angiopoietin-like 6 protein levels in type 2 diabetes mellitus patients
| Autor: | Rachna Gupta, Harmeet Singh Rehan, Vikaas Sharma, Ghan Shyam Pangtey, Lalit Kumar Gupta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male medicine.medical_specialty Short Communication 030209 endocrinology & metabolism Gastroenterology Correlation Angiopoietin 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine insulin resistance medicine Humans Hypoglycemic Agents Pharmacology (medical) Angiopoietin-Like Protein 6 Prospective Studies glucose Glycemic Aged Pharmacology Glycated Hemoglobin business.industry Type 2 Diabetes Mellitus Middle Aged medicine.disease Metformin 030104 developmental biology Endocrine signal Angiopoietin-like Proteins Treatment Outcome chemistry Diabetes Mellitus Type 2 Female Glycated hemoglobin business Biomarkers medicine.drug |
| Zdroj: | Indian Journal of Pharmacology |
| ISSN: | 1998-3751 0253-7613 |
| Popis: | AIMS: Angiopoietin-like growth factors (ANGPTLs) regulate glucose, lipid homeostasis, and insulin sensitivity. This study aimed to find whether long-term glycemic control (glycated hemoglobin [HbA1c]) has any correlation with serum ANGPTL6 levels in patients of type 2 diabetes mellitus. MATERIALS AND METHODS: It was an open-label, observational, prospective clinical study. Sixty-five participants (41 diabetic patients receiving daily dose of oral metformin for a minimum of 3 months and 24 matched controls) completed the study. A single venous blood sample was taken from each participant to determine serum HbA1c and serum ANGPTL6 levels. Comparison of serum ANGPTL6 levels according to the HbA1c levels, in groups A, B, and C ranging from 6.5%–8%, 8.1%–9.5%, and >9.5%, respectively, was done using Kruskal–Wallis H-test followed by pairwise comparisons. RESULTS: Serum HbA1c and serum ANGPTL6 levels were raised significantly (P < 0.05) in diabetic patients when compared with control participants. A positive correlation was observed between serum HbA1c and serum ANGPTL6 levels (r = 0.88, 95% confidence interval 0.81, 0.92). Mean ANGPTL6 level for Group A (n = 20) was 394.3 pg/ml, for Group B (n = 8) 692.8 pg/ml, and for Group C (n = 13) 896.2 pg/ml. CONCLUSIONS: Serum ANGPTL6 levels were significantly higher in type 2 diabetic patients in comparison with healthy controls. Poor glycemic control in diabetes mellitus as reflected by higher serum HbA1c levels is associated with raised serum ANGPTL6 levels. |
| Databáze: | OpenAIRE |
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