Regional correlation of structure and function in glaucoma, using the Disc Damage Likelihood Scale, Heidelberg Retina Tomograph, and visual fields
| Autor: | Helen V. Danesh-Meyer, John Chen Hsiang, Thiran Jayasundera, Judy Y.F. Ku, Taras Papchenko, Greg D. Gamble |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Scale (ratio) Adolescent Eye disease Optic Disk Vision Disorders Glaucoma Correlation Ophthalmology Linear regression Optic Nerve Diseases medicine Humans Child Tomography Heidelberg retina tomograph Intraocular Pressure Aged Aged 80 and over Likelihood Functions business.industry Lasers Middle Aged medicine.disease eye diseases Visual field Ophthalmoscopy medicine.anatomical_structure Visual Field Tests Female Ocular Hypertension sense organs Visual Fields business Optic disc |
| Zdroj: | Ophthalmology. 113(4) |
| ISSN: | 1549-4713 |
| Popis: | To evaluate relationships between the Disc Damage Likelihood Scale (DDLS), global and sectoral structural parameters provided by the Heidelberg Retina Tomograph (HRT), and global and regional functional loss in visual field (VF) testing.Consecutive observational case series.One hundred ten eyes from 110 patients categorized as glaucoma, glaucoma suspect, or normal.Participants were examined clinically to grade the DDLS score and were tested with HRT and Swedish Interactive Threshold Algorithm standard 24-2 VF tests. All tests were performed within 6 months of each other by examiners masked to the other findings. For each patient, the eye with the worse mean deviation (MD) of the VF test was enrolled in the study. Each field was divided into 6 sectors based on a published scheme, and the MD for each sector was calculated. The relationships among clinical DDLS score, HRT parameters, and VF indexes were analyzed by correlation coefficients and linear regression analysis.The relationship between the DDLS score, global and sectoral optic disc (HRT) parameters, and global and sectoral VF MDs was evaluated.The DDLS showed significant correlation with all global and sectoral VF indexes (r = -0.39 to -0.62, all Ps0.0001) and with sectoral rim area HRT measurements (r = -0.27 to -0.51, all Ps0.006). The DDLS correlated most strongly with superior and inferior regional data from HRT and VF, and less well with temporal and nasal data. Heidelberg Retina Tomograph rim area and rim volume were the only HRT parameters to correlate moderately with global VF MD (r = 0.30, P = 0.0018, and r = 0.28, P = 0.0030, respectively). Sectoral HRT rim area correlated moderately strongly with the corresponding sectoral VF MDs in the superior and inferior sectors (r = 0.35-0.46, P =0.0001-0.04).Clinical disc assessment and laser tomographic data that determine the state of the neuroretinal rim are associated with sensitivity loss in VF testing in corresponding regions. |
| Databáze: | OpenAIRE |
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