Macrophage activation and HIV infection: can the Trojan horse turn into a fortress?
| Autor: | A. Coaquette, G. Pancino, D. Perez-Bercoff, G. Herbein |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
CD4-Positive T-Lymphocytes
Transcription Genetic T-Lymphocytes CD40 Ligand Human immunodeficiency virus (HIV) Apoptosis HIV Infections Biology CD8-Positive T-Lymphocytes medicine.disease_cause Biochemistry Models Biological Virus Pathogenesis Immune system Acquired immunodeficiency syndrome (AIDS) medicine Animals Humans Molecular Biology Acquired Immunodeficiency Syndrome Monocyte Macrophages Trojan horse General Medicine Macrophage Activation medicine.disease Virology medicine.anatomical_structure Protein Biosynthesis Immunology Molecular Medicine |
| Zdroj: | Current molecular medicine. 2(8) |
| ISSN: | 1566-5240 |
| Popis: | Macrophages are infected early during HIV infection and are thought to play the role of a Trojan horse by spreading infection in tissues. Most recent studies point out to a more complex role for macrophages in HIV infection: macrophages could contribute to both host defense and viral persistence and pathogenesis. Infected macrophages are a reservoir for HIV and modulate apoptosis of T cells present in their vicinity. Also, a functional impairment of HIV-infected macrophages may play a role in AIDS pathogenesis. Nevertheless, both activation and differentiation of monocyte/macrophages can interfere with susceptibility of these cells to infection. Therefore, a wide variety of stimuli result in HIV suppression through macrophage activation. At present times, a dynamic view on the role of macrophages in HIV infection arises which indicates that macrophages are a target for the virus and at the same time regulate its replication. Therefore, macrophages are at the cross-road between protection and pathogenesis in HIV infection due to their involvement both as a viral target and a key modulator of non-specific and specific immune responses. Future studies will help unravel the cellular and molecular mechanisms that underlie HIV-macrophage interactions and might result in new vaccine and/or therapeutic strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|