Autologous immune enhancement therapy in a case of gall bladder cancer stage IV after surgical resection and chemotherapy yielding a stable non-progressive disease
| Autor: | Hiroshi Terunuma, Sulabhchandra Bhamare, Samuel J. K. Abraham, Helen C. Reena, Rajappa Senthilkumar, Senthilkumar Preethy, Vidyasagar Devaprasad Dedeepiya, Thangavelu Srinivasan, Pimparkar Prabhakar, Aniruddha Dharmadhikari |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Autologous immune enhancement therapy
Activated T lymphocytes autologous immune enhancement therapy Chemotherapy medicine.medical_specialty Bladder cancer natural killer cells business.industry medicine.medical_treatment gall bladder cancer General Medicine Immunotherapy medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 Surgery Radiation therapy Oncology medicine Combined Modality Therapy Radiology Nuclear Medicine and imaging immunotherapy business Survival rate Progressive disease |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 10, Iss 3, Pp 752-754 (2014) |
| ISSN: | 1998-4138 0973-1482 |
| Popis: | Advanced gall bladder cancer generally has a poor prognosis and also shows decreased response to conventional therapies like chemotherapy and radiotherapy. Though surgical resection is the most common approach followed, the 1-year survival rate is only 10%. Herein, we report the outcome of administration of autologous natural killer cell and activated T lymphocyte-based autologous immune enhancement therapy (AIET) in a case of gall bladder cancer stage IV which was progressing in spite of surgical resection and several sittings of chemotherapy. There were no adverse reactions after AIET. After three infusions of AIET, an improvement of the quality of life and general condition which is sustaining for more than 6 months and a substantial decrease in the CA 19-9 marker levels from 2938.22 U/mL before AIET to 511 U/mL, 5 months after AIET, in our experience make us recommend AIET along with other conventional treatments in similar cases. |
| Databáze: | OpenAIRE |
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