Interaction between postmenopausal hormone therapy and diabetes on cataract

Autor: Marie-Josée Aubin, Christy Costanian, Ellen E. Freeman, Ralf Buhrmann
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Canada
medicine.medical_specialty
Longitudinal study
Cross-sectional study
General Mathematics
medicine.medical_treatment
030209 endocrinology & metabolism
Type 2 diabetes
Canadian Longitudinal Study on Aging
Drug Administration Schedule
Original Studies
Cataract
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diabetes mellitus
Odds Ratio
medicine
Humans
Longitudinal Studies
Risk factor
Hormone therapy
Aged
Aged
80 and over
030219 obstetrics & reproductive medicine
business.industry
Applied Mathematics
Diabetes
Estrogen Replacement Therapy
Obstetrics and Gynecology
Glaucoma
Odds ratio
Middle Aged
medicine.disease
Confidence interval
3. Good health
Postmenopause
Cross-Sectional Studies
Logistic Models
Diabetes Mellitus
Type 2
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Female
Independent Living
business
Zdroj: Menopause (New York, N.y.)
ISSN: 1530-0374
1072-3714
Popis: Supplemental Digital Content is available in the text
Objective: We investigated whether postmenopausal hormone therapy (HT) use interacts with diabetes, a risk factor for several age-related eye diseases. Methods: A cross-sectional analysis of women involved in the Canadian Longitudinal Study on Aging was performed. The random sample comprised of 15,320 community-dwelling women between ages 45 and 85 years old sampled from areas adjacent to 11 data collection centers across Canada. Information on menopausal status and HT were collected by self-report. Data on diabetes and eye disease were obtained by self-report of a physician diagnosis. Multivariable logistic regression was used. Results: After adjusting for demographic, lifestyle, and health variables, a multiplicative interaction was identified such that HT use for 10 years or more was associated with a much higher odds of a report of cataract in women with type 2 diabetes (odds ratio = 2.44, 95% confidence interval 1.49, 3.99) but not in long-term HT users with no diabetes (odds ratio = 1.03, 95% confidence interval 0.87, 1.21) (interaction term P value = 0.013). HT use was not associated with glaucoma or macular degeneration. Conclusions: Long-term HT use and type 2 diabetes interact in their relationship with cataract. This novel finding should be confirmed. If confirmed, women with type 2 diabetes should be informed that long-term HT use increases their risk of cataract. Supplemental Digital Content is available in the text Video Summary:.
Databáze: OpenAIRE
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