A SPION-eicosane protective coating for water soluble capsules : evidence for on-demand drug release triggered by magnetic hyperthermia
| Autor: | Joseph C. Bear, Ivan P. Parkin, Laili Che Rose, Paul Southern, Sheng Qi, R. Ben Piggott, Andrew G. Mayes, Paul D. McNaughter |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
pharmacy
Pathology medicine.medical_specialty food.ingredient Materials science Nanoparticle Capsules 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences Gelatin Article food Coated Materials Biocompatible Microscopy Electron Transmission Coating Alkanes medicine Particle Size Magnetite Nanoparticles Drug Carriers Wax Multidisciplinary Temperature Water Capsule 021001 nanoscience & nanotechnology Ferrosoferric Oxide 0104 chemical sciences Drug Liberation Magnetic Fields Magnetic hyperthermia visual_art Drug delivery visual_art.visual_art_medium engineering 0210 nano-technology Drug carrier biological Biomedical engineering |
| Zdroj: | Scientific Reports |
| Popis: | An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems. |
| Databáze: | OpenAIRE |
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