Dietary supplement-related adverse events reported to the California Poison Control System
| Autor: | Angela J. Horn, Cathi E Dennehy, Candy Tsourounis |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Valerian medicine.medical_specialty Poison Control Centers Nausea Ephedra Poison control California Internal medicine Injury prevention medicine Adverse Drug Reaction Reporting Systems Humans Ingestion Child Adverse effect Retrospective Studies Pharmacology Plants Medicinal biology business.industry Data Collection Health Policy Retrospective cohort study biology.organism_classification medicine.disease Dietary Supplements Vomiting Female Medical emergency medicine.symptom business Drugs Chinese Herbal |
| Zdroj: | American Journal of Health-System Pharmacy. 62:1476-1482 |
| ISSN: | 1535-2900 1079-2082 |
| DOI: | 10.2146/ajhp040412 |
| Popis: | Purpose. Dietary supplement (DS)-related adverse events (AEs) reported to the California Poison Control System (CPCS) were studied. Methods. The CPCS database was used to search for all telephone calls from consumers concerning DS-related AEs received during the six-month period between April and September 2002. The calls were characterized according to the substance involved, the caller’s age (adult or pediatric), and the type of ingestion (accidental or intentional). Each exposure in which symptoms were reported was categorized as involving an AE. Each AE was assessed for severity and causality. Results. Data on a total of 1183 telephone calls were retrieved, of which 828 calls (70%) met the study’s inclusion criteria. DS exposure occurred in 389 adults (47%) and 438 children (53%). DS ingestion was accidental in 360 patients (43%) and intentional in 467 patients (56%). Exposure resulted in an AE in 480 patients (58%). AEs were reported in 353 patients (74%) who ingested products containing ephedra; other exposures frequently involved zinc, kava, creatine, and valerian. AEs were classified as moderate in 198 patients (41%) who ingested a DS and as severe in 40 patients (8%). One patient had a fatal reaction. Among the 480 AEs in DS-exposed consumers, the DS was classified as the definite cause of 1 AE ( |
| Databáze: | OpenAIRE |
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