A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata
| Autor: | Mao-Tien Kuo, Wu-Che Wen, Wan-Lin Tsou, Sheng-Yung Liu, Tzong-Huei Lee, Ching-Kuo Lee |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Ubiquinone
Pharmaceutical Science Pharmacognosy Analytical Chemistry law.invention Inhibitory Concentration 50 law Cell Line Tumor Drug Discovery LNCaP Humans Polyporales Antrodia Cytotoxicity Mycelium Polyporaceae Pharmacology biology Traditional medicine Plant Extracts Organic Chemistry biology.organism_classification Antineoplastic Agents Phytogenic Complementary and alternative medicine Fermentation Molecular Medicine Phytotherapy |
| Zdroj: | Planta medica. 73(13) |
| ISSN: | 0032-0943 |
| Popis: | Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC (50) values ranged from 0.13 +/- 0.02 to 6.09 +/- 0.07 microM. |
| Databáze: | OpenAIRE |
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