Ley/H: an endothelial-selective, cytokine-inducible, angiogenic mediator
| Autor: | James M. Woods, Michael V. Volin, Margaret M. Halloran, Stacie Phan, Phillip L. Campbell, William Carley, Catherine J. Haskell, Byron J. Anderson, Alisa E. Koch, Annika E. Bäcker, Peter J. Polverini |
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| Rok vydání: | 2000 |
| Předmět: |
Glycoconjugate
Angiogenesis medicine.medical_treatment Immunology Molecular Sequence Data Endothelial Growth Factors ABO Blood-Group System Neovascularization Mediator Lewis Blood Group Antigens In vivo Endopeptidases Synovial Fluid Immunology and Allergy Medicine Humans Cells Cultured chemistry.chemical_classification Chemotactic Factors business.industry Hydrolysis Cell Membrane Ligand (biochemistry) In vitro Cytokine chemistry Carbohydrate Sequence Solubility Antigens Surface Cancer research Cytokines Angiogenesis Inducing Agents Endothelium Vascular medicine.symptom business |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 164(9) |
| ISSN: | 0022-1767 |
| Popis: | Endothelial cells (ECs) are key participants in angiogenic processes that characterize tumor growth, wound repair, and inflammatory diseases, such as human rheumatoid arthritis (RA). We and others have shown that EC molecules, such as soluble E-selectin, mediate angiogenesis. Here we describe an EC molecule, Lewisy-6/H-5-2 glycoconjugate (Ley/H), that shares some structural features with the soluble E-selectin ligand, sialyl Lewisx (sialyl Lex). One of the main previously recognized functions of Lewisy is as a blood group glycoconjugate. Here we show that Ley/H is rapidly cytokine inducible, up-regulated in RA synovial tissue, where it is cell-bound, and up-regulated in the soluble form in angiogenic RA compared with nonangiogenic osteoarthritic joint fluid. Soluble Ley/H also has a novel function, for it is a potent angiogenic mediator in both in vitro and in vivo bioassays. These results suggest a novel paradigm of soluble blood group Ags as mediators of angiogenic responses and suggest new targets for therapy of diseases, such as RA, that are characterized by persistent neovascularization. |
| Databáze: | OpenAIRE |
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