De Novo Designed Coiled-Coil Proteins with Variable Conformations as Components of Molecular Electronic Devices
| Autor: | Clara Shlizerman, Alexander Atanassov, Nurit Ashkenasy, Gonen Ashkenasy, Inbal Berkovich |
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| Rok vydání: | 2010 |
| Předmět: |
Coiled coil
Protein Conformation Surface Properties Cellular functions Proteins Membranes Artificial Device Properties General Chemistry Antiparallel (biochemistry) Biochemistry Catalysis chemistry.chemical_compound Crystallography Dipole Colloid and Surface Chemistry Monomer chemistry Materials Testing Monolayer Gold Electronics |
| Zdroj: | Journal of the American Chemical Society. 132:5070-5076 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | Conformational changes of proteins are widely used in nature for controlling cellular functions, including ligand binding, oligomerization, and catalysis. Despite the fact that different proteins and artificial peptides have been utilized as electron-transfer mediators in electronic devices, the unique propensity of proteins to switch between different conformations has not been used as a mechanism to control device properties and performance. Toward this aim, we have designed and prepared new dimeric coiled-coil proteins that adopt different conformations due to parallel or antiparallel relative orientations of their monomers. We show here that controlling the conformation of these proteins attached as monolayers to gold, which dictates the direction and magnitude of the molecular dipole relative to the surface, results in quantitative modulation of the gold work function. Furthermore, charge transport through the proteins as molecular bridges is controlled by the different protein conformations, producing either rectifying or ohmic-like behavior. |
| Databáze: | OpenAIRE |
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