Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens
| Autor: | GC Kahn, Donald S. Davies, JH Saunders, Alan R. Boobis, Fletcher, MJ Brodie |
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| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Pathology Cytochrome Biology Mixed Function Oxygenases Liver disease Cytochrome P-450 Enzyme System Cigarette smoking Internal medicine medicine Animals Humans Pharmacology (medical) Monooxygenase activity Wedge Biopsy Pharmacology Human liver Biopsy Needle Proteins NADH Dehydrogenase medicine.disease Rats Endocrinology Needle biopsy Microsomes Liver Microsome biology.protein Aryl Hydrocarbon Hydroxylases Oxidoreductases Research Article |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1980.tb04790.x |
| Popis: | 1 Methods are described for the determination of mixed function oxidase activity in microsomal fractions from percutaneous needle biopsies of human liver. 2 Activities of needle biopsy samples were comparable with those of wedge biopsy sample obtained at laparotomy from different subjects. 3 Although cytochrome P-450 content of liver from rat and man was similar, human AHH activity was only 10% of that in the rat. 4 In biopsies with preserved hepatic architecture, AHH activity and cytochrome P-450 content showed a significant positive correlation. 5 Cigarette smoking significantly increased both AHH activity and turnover number, but not cytochrome P-450 content, of biopsies with normal architecture. 6 The presence of liver disease caused a significant decrease in AHH activity and cytochrome P-450 content. |
| Databáze: | OpenAIRE |
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