Factors influencing the severity of behavioral phenotype in autism spectrum disorders: Implications for research
| Autor: | Caihong Sun, Zhanbin Xu, Xinxi Zhang, Wei Xia, Mingyang Zou, Lijie Wu, Lei Chen, Yongjuan Ma, Jing Kang, Jia Wang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
China Adolescent Autism Spectrum Disorder Severity of Illness Index Autism Diagnostic Observation Schedule 03 medical and health sciences 0302 clinical medicine Adaptation Psychological mental disorders Severity of illness otorhinolaryngologic diseases medicine Humans Raw score 0501 psychology and cognitive sciences Child Social Behavior Biological Psychiatry Intelligence Tests Intelligence quotient 05 social sciences Age Factors Reproducibility of Results Confounding Factors Epidemiologic medicine.disease Vineland Adaptive Behavior Scale Psychiatry and Mental health Phenotype Convergent validity Autism spectrum disorder Child Preschool Behavior Rating Scale Autism Female Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology Clinical psychology |
| Zdroj: | Psychiatry Research. 261:290-297 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2017.12.084 |
| Popis: | The phenotypic heterogeneity of Autism Spectrum Disorders (ASD) presents particular research challenges in the assessment of symptom severity, while the standardized Autism Diagnostic Observation Schedule (ADOS) scores present a severity metric, namely calibrated severity scores (CSS) that are relatively impervious to individual characteristics. To date, no studies have examined the convergent validity of CSS in Chinese sample populations. The present study investigated the validity of the ADOS-CSS using a sample of 321 children aged 2-18 years with ASD, and developed upon existing literature examining the influence of non-ASD-specific characteristics on other types of measures including Autism Diagnostic Interview-Revised (ADI-R), Social Responsiveness Scale (SRS), and Vineland Adaptive Behavior Scales (VABS). As expected, the findings revealed that the CSS were less influenced than ADOS-RAW scores by the demographic and developmental-level variables. Moreover, compared to the ADOS-CSS, the ADI-R, SRS and VABS were still strongly correlated with confounding factors, such as chronological age, intelligence quotients, and language-level. The results of this study corroborate the utilization of CSS as a more valid indicator of ASD severity than raw scores from ADOS and other instruments. |
| Databáze: | OpenAIRE |
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