Fe-S Clusters Emerging as Targets of Therapeutic Drugs
| Autor: | Nadine El Banna, Amélie Heneman, Dorothée Baïlle, Laurence Vernis, Meng-Er Huang, Elie Hatem |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Iron-Sulfur Proteins Aging Metal ions in aqueous solution Iron Sulfur metabolism Review Article Nitric Oxide Biochemistry Redox Nitric oxide Metal 03 medical and health sciences chemistry.chemical_compound Cluster (physics) Molecule Animals Humans Molecular Targeted Therapy lcsh:QH573-671 chemistry.chemical_classification Reactive oxygen species lcsh:Cytology Cell Biology General Medicine Combinatorial chemistry 030104 developmental biology chemistry visual_art visual_art.visual_art_medium Reactive Oxygen Species Oxidation-Reduction Copper Sulfur |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2017 (2017) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Fe-S centers exhibit strong electronic plasticity, which is of importance for insuring fine redox tuning of protein biological properties. In accordance, Fe-S clusters are also highly sensitive to oxidation and can be very easily alteredin vivoby different drugs, either directly or indirectly due to catabolic by-products, such as nitric oxide species (NOS) or reactive oxygen species (ROS). In case of metal ions, Fe-S cluster alteration might be the result of metal liganding to the coordinating sulfur atoms, as suggested for copper. Several drugs presented through this review are either capable of direct interaction with Fe-S clusters or of secondary Fe-S clusters alteration following ROS or NOS production. Reactions leading to Fe-S cluster disruption are also reported. Due to the recent interest and progress in Fe-S biology, it is very likely that an increasing number of drugs already used in clinics will emerge as molecules interfering with Fe-S centers in the near future. Targeting Fe-S centers could also become a promising strategy for drug development. |
| Databáze: | OpenAIRE |
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