Gender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder
| Autor: | Wei-Tsung Kao, Chen-Lin Chang, Chi-Hung Lin, Shang-Liang Wu, Shang-Lun Lin, For-Wey Lung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
hypertension lcsh:RC435-571 Population 03 medical and health sciences 0302 clinical medicine Internal medicine lcsh:Psychiatry mental disorders medicine risk factors education Gender disparity National Health Insurance Database Original Research Psychiatry education.field_of_study Proportional hazards model business.industry major depressive disorder (MDD) Hazard ratio medicine.disease 030227 psychiatry Psychiatry and Mental health Relative risk Propensity score matching Antidepressant Major depressive disorder business propensity score matching (PSM) 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Psychiatry, Vol 10 (2019) Frontiers in Psychiatry |
| ISSN: | 1664-0640 |
| Popis: | Objects: The aim of our study was to investigate whether major depressive disorder (MDD) increased the risk of hypertension using propensity score matching (PSM) in patients with MDD in Taiwan.Methods: In this study, we recruited all samples from a random sample sub-dataset of one million insured individuals from 2005. A total of 743,114 outpatients were included in our study. We used PSM (nearest neighbor matching) stratified by age, hospital level, insurance amount, and Charlson Comorbidity Index score.Results: The hazard ratio (HR) of hypertension was significantly greater in the male MDD outpatients (HR = 1.116, P = 0.004) than in the female MDD outpatients (HR = 0.93, P = 0.02). Using PSM, we selected 27,988 outpatients with hypertension and 27,988 outpatients without hypertension for a nested case–control study. In this analysis, female outpatients with MDD (relative risk = 0.852) had lower risks of hypertension. Male outpatients without/with MDD (relative risk = 1.987/3.018) showed a synergistic interaction with gender in which male patients had a higher risk of hypertension in a multiplicative model. Furthermore, MDD appeared to have an interaction effect with gender (HR = 1.82, P < 0.001) in the proportional hazards model analysis. Antidepressant use also increased the risk of hypertension (HR = 1.16, P < 0.001).Conclusions: There was gender disparity in the risk of hypertension in subjects with MDD. MDD outpatients who used antidepressants had a higher risk of suffering from hypertension. A large-scale, population-based study is warranted to generalize these results in the future. |
| Databáze: | OpenAIRE |
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