Vitamin K Deficiency Bleeding: An Ounce of Prevention
| Autor: | Christopher McPherson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Parents
Vitamin Pediatrics medicine.medical_specialty Vitamin K Hemorrhage Critical Care and Intensive Care Medicine Critical Care Nursing 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oral administration 030225 pediatrics Epidemiology medicine Humans Child business.industry Public health Infant Newborn Infant General Medicine Vitamin K Deficiency Bleeding Clotting cascade chemistry Pediatrics Perinatology and Child Health Oral vitamin Intramuscular injection business Intracranial Hemorrhages 030217 neurology & neurosurgery |
| Zdroj: | Neonatal Network. 39:356-362 |
| ISSN: | 1539-2880 0730-0832 |
| DOI: | 10.1891/0730-0832/11-t-630 |
| Popis: | Vitamin K is a fat-soluble vitamin essential for the formation of factors in the clotting cascade. Newborns are born with insufficient levels of vitamin K, resulting in high risk for vitamin K deficiency bleeding (VKDB). Vitamin K deficiency bleeding can occur in the first week of life (“classic” VKDB) and also between 2 weeks and 3 months of age (“late” VKDB). Vitamin K deficiency bleeding can present as bleeding in the skin or gastrointestinal tract, with as many as half of affected neonates experiencing intracranial bleeding. A single intramuscular injection of vitamin K effectively prevents both classic and late VKDB. Although intramuscular vitamin K is safe and effective, VKDB has reemerged because of decreased utilization. Parents refuse intramuscular vitamin K for a variety of reasons, including a disproven association with childhood cancer, the desire to avoid exposure to additives, and valid concerns about early neonatal pain. Many parents request oral vitamin K, an inferior alternative strategy that requires multiple doses utilizing products not designed for neonatal oral administration. In this setting, health care professionals must understand the epidemiology of VKDB and compassionately counsel parents to assuage concerns. Delivery of intramuscular vitamin K to all newborns remains a public health imperative, benefitting thousands of infants annually. |
| Databáze: | OpenAIRE |
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