Effect of combination of peripheral oxytocin and naltrexone at subthreshold doses on food intake, body weight and feeding-related brain gene expression in male rats
| Autor: | Allen S. Levine, David G. Christian, Pawel K. Olszewski, Mitchell A. Head, Anica Klockars |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Gene Expression Experimental and Cognitive Psychology Context (language use) Nucleus accumbens Oxytocin Naltrexone 03 medical and health sciences Behavioral Neuroscience Eating 0302 clinical medicine Opioid receptor Internal medicine medicine Animals Humans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Meal business.industry 05 social sciences Body Weight Antagonist Brain Rats Endocrinology Hypothalamus business human activities 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Physiologybehavior. 238 |
| ISSN: | 1873-507X |
| Popis: | In a recent case report involving a male with hypothalamic obesity, concurrent administration of oxytocin (OT) and an opioid receptor antagonist, naltrexone (NTX), synergistically affected energy balance. Here, by using laboratory rats, we examined whether the reported synergy between OT and NTX in the context of food intake extends beyond that one unique case. We found that intravenous OT+NTX combination, at doses subthreshold for each of the drugs individually, decreased episodic consumption of a 10% sucrose solution in non-deprived animals. Daily administration of OT and NTX just before a scheduled, 2-hour, high-fat high-sugar (HFHS) meal over 24 days, decreased cumulative HFHS diet intake, but without a change in body weight due to compensatory standard chow intake during the remainder of the day. The NTX-OT treatment affected expression of several feeding-related genes in the hypothalamus, brain stem and nucleus accumbens, brain regions essential for the regulation of energy- and reward-driven consumption. We conclude that OT and NTX act synergistically to decrease food consumption in rats and that this transient effect is accompanied by changes in brain processes relevant to feeding. |
| Databáze: | OpenAIRE |
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