The Effects of Transtracheal Gas Delivery on Central Inspiratory Neuromuscular Drive
| Autor: | Graham C. Scott, Patrick R. Quigley, Kent L. Christopher, Riley R Scott, James M. Hinson, Michael H. Metzler |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Neuromuscular Junction Severe copd Critical Care and Intensive Care Medicine Work of breathing Catheters Indwelling medicine Humans Lung Diseases Obstructive Lung Work of Breathing Inspiratory tidal volume Pulmonary Gas Exchange business.industry Respiratory disease Mean age Middle Aged medicine.disease Respiratory Muscles Models Structural Oxygen Trachea Catheter medicine.anatomical_structure Anesthesia Female Cardiology and Cardiovascular Medicine business Respiratory minute volume |
| Zdroj: | Chest. 104:1199-1202 |
| ISSN: | 0012-3692 |
| Popis: | Previous studies have shown transtracheal delivery of low-flow oxygen (TTO) decreases inspired minute ventilation (Veinsp) and have postulated that this would result in a decrease in the work of breathing (WOB). We hypothesized that a fall in central inspiratory neuromuscular drive (CIND) with TTO would reflect a fall in WOB. We measured resting ventilatory parameters (RVP) and CIND by the mouth occlusion pressure technique (MOP) at different gas flow rates through the catheter in 21 subjects (13 men, 8 women; mean age, 60 +/- 10.6 years) with severe COPD with a mature intratracheal oxygen catheter (ITOC). We also constructed a lung/chest wall analog (LCA) to determine if flow through the catheter would alter pressure changes during inspiration. Inspiratory tidal volume (Vtinsp) and minute ventilation (Veinsp) decreased proportionally to the gas flow rate through the catheter. However, with increasing flow through the catheter, P0.1 increased in the LCA, presumably due to the Bernoulli effect. The lack of a similar change in the subject group suggests that CIND does, in fact, fall, and that possibly there is a decrease in WOB. This effect may be of benefit to patients with severe COPD. |
| Databáze: | OpenAIRE |
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