Independent risk factors for the co-colonization of vancomycin-resistant Enterococcus faecalis and methicillin-resistant Staphylococcus aureus in the region most endemic for vancomycin-resistant Staphylococcus aureus isolation
| Autor: | F. Ahmed, Pradeep Bathina, Judy Moshos, A. M. Omotola, Amber Khan, Keith S. Kaye, Kevin Ho, Miriam T. Levine, Sagar Mallikethi Lepakshi Reddy, M. Mustapha, U. Suhrawardy, Dror Marchaim, Kavyashri Jagadeesh, L. B. Willis, Emily T. Martin, Diixa Patel, Michael J. Rybak, M. Ajamoughli, Kayoko Hayakawa, Srinivasa Kamatam, Jason M. Pogue, Bharath Sunkara, K. P. Lee |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Male Methicillin-Resistant Staphylococcus aureus medicine.medical_specialty Vancomycin-resistant Staphylococcus aureus Drug resistance medicine.disease_cause Enterococcus faecalis Microbiology Medical microbiology Risk Factors Vancomycin Drug Resistance Bacterial medicine Odds Ratio Humans Gram-Positive Bacterial Infections Aged Retrospective Studies Aged 80 and over biology business.industry Coinfection Retrospective cohort study General Medicine biochemical phenomena metabolism and nutrition Middle Aged Staphylococcal Infections bacterial infections and mycoses biology.organism_classification medicine.disease Methicillin-resistant Staphylococcus aureus Infectious Diseases Staphylococcus aureus Case-Control Studies Female business |
| Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 32(6) |
| ISSN: | 1435-4373 |
| Popis: | In the majority of cases of vancomycin-resistant Staphylococcus aureus (VRSA), vancomycin-resistant Enterococcus faecalis (VR E. faecalis) served as the vanA donor to S. aureus. Previous studies that evaluated the risk factors for co-colonization with VRE and MRSA did not differentiate between VR E. faecalis and VR E. faecium. This study aimed to identify variables associated with VR E. faecalis and MRSA co-colonization. A retrospective case-control study from January 2008 to December 2009 was conducted at the Detroit Medical Center. Data were extracted from charts and pharmacy records. Unique patients co-colonized with VR E. faecalis and MRSA (defined as isolation of MRSA within 7 days of VR E. faecalis isolation) were compared with patients with VR E. faecalis who were not co-colonized with MRSA. A total of 546 patients with VR E. faecalis isolation were identified. 85 (15.6 %) VR E. faecalis patients were co-colonized with MRSA and 461 (84.4 %) VR E. faecalis patients were not co-colonized with MRSA. The mean age of the study cohort was 65.9 ± 16.4 years, 424 (77.7 %) were African-American, and 270 (49.5 %) were residing in long-term care institutions. Independent predictors of co-colonization of VR E. faecalis and MRSA were male gender, impaired consciousness, ICU stay prior to VR E. faecalis isolation, indwelling devices, and isolation of VR E. faecalis from wounds. MRSA was frequently isolated from the same culture specimen as VR E. faecalis (n = 39, 45.9 %), most commonly from wounds. This large study of patients with VR E. faecalis identified the severity of illness, indwelling devices, and chronic wounds as independent predictors of co-colonization with VR E. faecalis and MRSA. |
| Databáze: | OpenAIRE |
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