Perspective: Therapeutic Potential of Flavonoids as Alternative Medicines in Epilepsy
| Autor: | Un Ju Jung, Gyeong Joon Moon, Jae Young Kwon, Sang Ryong Kim, Min-Tae Jeon, Dong Woon Kim |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) Neurological disorder Bioinformatics Temporal lobe 03 medical and health sciences Epilepsy 0302 clinical medicine Quality of life antiepilepsy medicine In patient antiepileptic drugs Adverse effect Pathological Nutrition and Dietetics business.industry medicine.disease Granule cell dispersion 030104 developmental biology Perspective flavonoids epilepsy business granule cell dispersion 030217 neurology & neurosurgery Food Science |
| Zdroj: | Advances in Nutrition |
| ISSN: | 2161-8313 |
| DOI: | 10.1093/advances/nmz047 |
| Popis: | Epilepsy is a chronic neurological disorder that affects many people worldwide. Temporal lobe epilepsy is the most common and most studied type of epilepsy, but the pathological mechanisms underlying this condition are poorly understood. More than 20 antiepileptic drugs (AEDs) have been developed and used for the treatment of epilepsy; however, 30% of patients still experience uncontrolled epilepsy and associated comorbidities, which impair their quality of life. In addition, various side effects have been reported for AEDs, such as drowsiness, unsteadiness, dizziness, blurred or double vision, tremor (shakiness), greater risk of infections, bruising, and bleeding. Thus, critical medical needs remain unmet for patients with uncontrolled epilepsy. Flavonoids belong to a subclass of polyphenols that are widely present in fruits, vegetables, and certain beverages. Recently, many studies have reported that some flavonoids elicit various beneficial effects in patients with epilepsy without causing the side effects associated with conventional medical therapies. Moreover, flavonoids may have a property of regulating microRNA expression associated with inflammation and cell survival. These findings suggest that flavonoids, which are more effective but impose fewer adverse effects than conventional AEDs, could be used in the treatment of epilepsy. |
| Databáze: | OpenAIRE |
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