Diffuse cerebral atrophy and reversible polyneuropathy in a patient with chronic Bromvalerylurea intoxication: a case report
| Autor: | Shiori Asano, Shigeki Yamaguchi, Makiko Inaoka, Yoichi Kanatsuka, Izumi Mori, Kensuke Nakazawa |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Decreased nerve conduction velocity Polyneuropathies Weight loss Diffuse brain atrophy Humans Hypnotics and Sedatives Medicine Gait Disorders Neurologic Tomography Emission-Computed Single-Photon Cerebral atrophy Gait Disturbance business.industry Brain Extremities medicine.disease Magnetic Resonance Imaging Peripheral neuropathy Anesthesia Chronic Disease Maximum dose Fluid Therapy Neurology (clinical) Atrophy Bromisovalum medicine.symptom business Polyneuropathy |
| Zdroj: | Rinsho Shinkeigaku. 60:795-798 |
| ISSN: | 1882-0654 0009-918X |
| DOI: | 10.5692/clinicalneurol.cn-001471 |
| Popis: | A 37-year-old man who had been on bromvalerylurea (BU) medication for 11 years at a maximum dose of 2,400 mg per day for headache therapy was admitted to our hospital due to gait disturbance. He had weight loss and exanthema all over his body. Cognitive dysfunction, intellectual deterioration, attention disturbance, decreased muscle strength, and decreased vibratory sense in the lower limbs were observed. Brain MRI showed diffuse brain atrophy, and a peripheral nerve conduction examination revealed decreased nerve conduction velocity and action potential amplitude in the extremities. We diagnosed him with chronic BU intoxication based on pseudohyperchloremia, BU detected in the blood, and bromide elevation. By discontinuing BU and performing intravenous infusion, neurological symptoms and exanthema were improved, and peripheral nerve conduction examination findings also improved. There are few reports of peripheral neuropathy cases of chronic BU intoxication; herein we report one such case along with previously reported cases. |
| Databáze: | OpenAIRE |
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