Study of effects of mifepristone on full-term pregnancies
| Autor: | Priyanka Sharma, Kushla Pathania, Uday Bhanu Rana |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Term Birth Pregnancy Trimester Third Bishop score 03 medical and health sciences 0302 clinical medicine Hormone Antagonists Pregnancy medicine Humans Labor Induced Prospective Studies Adverse effect Full Term 030219 obstetrics & reproductive medicine Vaginal delivery Obstetrics business.industry Obstetrics and Gynecology Mifepristone medicine.disease Clinical Practice Treatment Outcome 030220 oncology & carcinogenesis Female Labour Induction business medicine.drug Cervical Ripening |
| Zdroj: | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 40(2) |
| ISSN: | 1364-6893 |
| Popis: | The induction of labour is required for various indications in obstetrics. Various regimens and drugs are advocated for use in labour induction. Mifepristone is one such drug which has a definite role in first and second-trimester pregnancy terminations. However, its role in the third-trimester is still being reviewed. In the present study, the effect of mifepristone on cervical ripening was assessed and results interpreted.Impact statementWhat is already known on the subject? The role of mifepristone in termination of pregnancies at term is controversial. Some studies report onset of labour after giving mifepristone whereas others do not report any significant role.What do the results of the study add? Mifepristone has a role in improving Bishop score and can be used as a pre-induction cervical ripening agent before using other methods for labour induction. It does not report any adverse effects on the mother or foetus.What are the implications of these findings for clinical practice and/or further research? Mifepristone needs to be studied more in term pregnancies as induction of labour is increasingly required in today's scenario for various reasons. However, its role in improving the Bishop score as found in this study helps in decreasing dose of other labour inducing agents. |
| Databáze: | OpenAIRE |
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