Xiao-Qing-Long Tang Prevents Cardiomyocyte Hypertrophy, Fibrosis, and the Development of Heart Failure with Preserved Ejection Faction in Rats by Modulating the Composition of the Gut Microbiota
| Autor: | Jiye Chen, Yongcheng Wang, Guofeng Zhou, Jinlong Yang, Xiao-wei Han, Du-Fang Ma, Zhao-Yu Li, Yue-Hua Jiang, Xiao Li, Chen-Yu Chi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Article Subject lcsh:Medicine Physiology Administration Oral Inflammation Cardiomegaly 030204 cardiovascular system & hematology Gut flora digestive system General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Immune system fluids and secretions Oral administration Fibrosis medicine Animals Myocytes Cardiac Feces Heart Failure Rats Inbred Dahl General Immunology and Microbiology biology business.industry lcsh:R Stroke Volume General Medicine biology.organism_classification medicine.disease Gastrointestinal Microbiome Rats stomatognathic diseases Disease Models Animal 030104 developmental biology Blood pressure Heart failure medicine.symptom business Research Article Drugs Chinese Herbal |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2019 (2019) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Background. Changes in the gut microbiota are associated with cardiovascular disease progression. Xiao-Qing-Long Tang (XQLT), a traditional herbal formula, has an anti-inflammatory effect and regulates the steady state of the immune system, which is also associated with the progression of heart failure with preserved ejection faction (HFpEF). In this study, we investigated whether XQLT could contribute to prevent the development of HFpEF and whether the modulation of the gut microbiota by this herbal formula could be involved in such effect. Methods. The gut microbiota, SCFAs, the histology/function of the heart, and systolic blood pressure were examined to evaluate the effect of XQLT on the gut microbiota and the progression of HFpEF after oral administration of XQLT to model rats. Furthermore, we evaluated, through fecal microbiota transplantation experiments, whether the favorable effects of XQLT could be mediated by the gut microbiota. Results. Oral administration of XQLT contributed to the reduction of elevated blood pressure, inflammation, and compensatory hypertrophy, features that are associated with the progression of HFpEF. The gut microbiota composition, SCFA levels, and intestinal mucosal histology were improved after treatment with XQLT. Moreover, fecal transfer from XQLT-treated rats was sufficient to prevent the progression of HFpEF. Conclusions. These data suggested that XQLT prevented the development of HFpEF in model rats by regulating the composition of the gut microbiota. |
| Databáze: | OpenAIRE |
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