Lineage-specific roles of hedgehog-GLI signaling during mammalian kidney development

Autor:	Christopher J. Rowan, Katryna Stronks, Norman D. Rosenblum, Robert D'Cruz
Rok vydání:	2018
Předmět:	Nephrology medicine.medical_specialty 030232 urology & nephrology Morphogenesis Kidney development Embryonic Development Nephron 030204 cardiovascular system & hematology urologic and male genital diseases Kidney Zinc Finger Protein GLI1 03 medical and health sciences Mice 0302 clinical medicine Stroma Internal medicine Medicine Animals Humans Cell Lineage Hedgehog Proteins Hedgehog business.industry Embryogenesis Gene Expression Regulation Developmental Embryo Mammalian Embryonic stem cell Cell biology medicine.anatomical_structure Pediatrics Perinatology and Child Health Models Animal Mutation business Signal Transduction
Zdroj:	Pediatric nephrology (Berlin, Germany). 35(5)
ISSN:	1432-198X
Popis:	Aberrant hedgehog (Hh) signaling during embryogenesis results in various severe congenital abnormalities, including renal malformations. The molecular mechanisms that underlie congenital renal malformations remain poorly understood. Here, we review the current understanding of the lineage-specific roles of Hh signaling during renal morphogenesis and how aberrant Hh signaling during embryonic kidney development contributes to renal malformation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a200289578a04d07078ade1e6e61c04a https://pubmed.ncbi.nlm.nih.gov/30923969 Zobrazit plný text záznamu Full text from SpringerLink