A cohort study of health effects of human T-cell lymphotropic virus type I infection in Jamaican children
| Autor: | William A. Blattner, Beverley Cranston, Barrie Hanchard, Stefan Z. Wiktor, Elizabeth M. Maloney, Sylvia Cohn, Wendell Miley, Terry L. Thomas, Ernest Pate, P. Palmer, Norma Kim |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Jamaica Eczema Rate ratio Cohort Studies Internal medicine Seborrheic dermatitis medicine Proportional Hazards Models Neurologic Examination Reflex Abnormal Proportional hazards model business.industry Incidence (epidemiology) Incidence Anemia medicine.disease HTLV-I Infections Confidence interval Dermatitis Seborrheic Breast Feeding Pediatrics Perinatology and Child Health Immunology Cohort business Breast feeding Cohort study |
| Zdroj: | Pediatrics. 112(2) |
| ISSN: | 1098-4275 |
| Popis: | Objective. Human T-cell lymphotropic virus type I (HTLV-I) infection in childhood is believed to play an important role in risk for adult T-cell leukemia/lymphoma. Although HTLV-I is known to be associated with infective dermatitis in childhood, other HTLV-I-associated morbidity in children has not been well studied. We sought to determine the HTLV-I-associated health effects in Jamaican children. Methods. We compared incidence rates of several health outcomes in 28 HTLV-I-infected and 280 uninfected children clinically followed from age 6 weeks to a maximum of 10 years. Cox proportional hazards regression analysis was used to analyze these prospectively collected data, adjusting for confounding effects of other variables as necessary. Results. HTLV-I-infected children had significantly higher incidence rates of seborrheic dermatitis (rate ratio [RR] = 4.8, 95% confidence interval [CI] = 1.9–12.5), eczema (RR = 3.1, CI = 1.2–7.9) and persistent hyperreflexia (RR = 3.7, CI = 1.6–8.2). Additionally, HTLV-I infected children had increased rates of severe anemia (RR = 2.5, CI = 0.8–7.9) and abnormal lymphocytes (RR = 2.4, CI = 0.8–7.6) that were of borderline statistical significance. Conclusions. Our study suggests that HTLV-I-associated skin diseases of childhood may include seborrheic dermatitis and eczema. Additionally, these data suggest that persistent hyperreflexia of the lower limbs may be an early sign of HTLV-I-associated neurologic involvement in children. Expansion and continued clinical observation of this cohort would be valuable. |
| Databáze: | OpenAIRE |
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