Antibacterial effect of composite resin foundation material incorporating quaternary ammonium polyethyleneimine nanoparticles
| Autor: | Yoav Pietrokovski, Natan Zaltsman, Dana Kesler-Shvero, Ilana Nisimov, Nurit Beyth |
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| Rok vydání: | 2016 |
| Předmět: |
Actinomyces viscosus
Materials science Composite number Nanoparticle 02 engineering and technology In Vitro Techniques Composite Resins Microbiology Disk Diffusion Antimicrobial Tests Streptococcus mutans 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Polyethyleneimine Ammonium Agar diffusion test biology 030206 dentistry 021001 nanoscience & nanotechnology Antimicrobial biology.organism_classification Anti-Bacterial Agents Quaternary Ammonium Compounds chemistry Nanoparticles Oral Surgery 0210 nano-technology Antibacterial activity Nuclear chemistry |
| Zdroj: | The Journal of Prosthetic Dentistry. 116:603-609 |
| ISSN: | 0022-3913 |
| DOI: | 10.1016/j.prosdent.2016.02.022 |
| Popis: | Statement of problem As caries is the most frequent cause of the failure of composite resin-based restorations, composite resins with antibacterial properties are desirable. However, whether quaternary ammonium polyethyleneimine nanoparticles can be effectively incorporated is unknown. Purpose The purpose of this in vitro study was to evaluate the antibacterial activity against Streptococcus mutans and Actinomyces viscosus of a foundation material incorporating quaternary ammonium polyethyleneimine (QPEI) nanoparticles. Material and methods QPEI antimicrobial nanoparticles were incorporated in a commercially available foundation material (Q Core; BJM Laboratories Ltd) at 1% wt/wt. Antibacterial efficacy against S mutans (10 6 colony-forming units [CFU]/mL) and A viscosus (10 6 CFU/mL) was examined by the direct contact test (DCT), and the agar diffusion test (ADT) with and without surface polishing. Bacterial outgrowth was recorded with a spectrophotometer. Results Growth of S mutans and A viscosus was inhibited, showing a decrease by 6 orders of magnitude in bacterial viability in specimens incorporating the nanoparticles, even after polishing the foundation material ( P Conclusions Antibacterial properties can be achieved in a commercially available foundation material by incorporating polycationic antibacterial nanoparticles. This antibacterial effect did not diminish after surface polishing. |
| Databáze: | OpenAIRE |
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