A New Case of γ-Heavy Chain Disease
| Autor: | Renato Di Guglielmo, Vercelli D, Emanuela Castigli, Federico Cozzolino, A Becucci |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Electrophoresis
Agar Gel Immunodiffusion Gamma Heavy Chain Disease business.industry Immunoglobulin gamma-Chains Complete remission Electrophoresis Cellulose Acetate Hematology Disease Urine Middle Aged Malignancy medicine.disease Hodgkin Disease Abnormal protein Pathogenesis Immunology Humans Medicine Female Hinge region business Heavy Chain Disease |
| Zdroj: | Scandinavian Journal of Haematology. 28:145-150 |
| ISSN: | 0036-553X |
| Popis: | The detection of a γ-heavy chain disease protein in the serum and urine of a patient with a history of Hodgkin's disease in complete remission is reported. The protein has been characterized as a γ1 dimer, MW 66000, beginning at Asp 221 residue in the hinge region. No clinical or laboratory findings of malignancy have been observed in the patient since the abnormal protein was detected. The pathogenesis of this association, unreported to date, is discussed on the basis of previously administered high-dose anti-neoplastic treatments and of immunological impairment. |
| Databáze: | OpenAIRE |
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