Antipanic-like effect of esketamine and buprenorphine in rats exposed to acute hypoxia

Autor: Jhonatan Christian Maraschin, Sâmia R.L. Joca, Paloma Molina Hernandes, Telma Gonçalves Carneiro Spera de Andrade, Alana Tercino Frias, Elisabeth Aparecida Audi, Frederico Guilherme Graeff, Hélio Zangrossi, Lucas Motta Martinez, Matheus Fitipaldi Batistela
Přispěvatelé: Universidade de São Paulo (USP), Aarhus University, Behavioural Neurosciences Institute (INeC), Universidade Estadual de Maringá (UEM), Universidade Estadual Paulista (UNESP)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Maraschin, J C, Frias, A T, Hernandes, P M, Batistela, M F, Martinez, L M, Joca, S R L, Graeff, F G, Audi, E A, Spera de Andrade, T G C & Zangrossi, H 2022, ' Antipanic-like effect of esketamine and buprenorphine in rats exposed to acute hypoxia ', Behavioural Brain Research, vol. 418, 113651 . https://doi.org/10.1016/j.bbr.2021.113651
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
DOI: 10.1016/j.bbr.2021.113651
Popis: Made available in DSpace on 2022-04-28T19:47:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-10 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The antidepressant effect of ketamine has been widely acknowledged and the use of one of its enantiomers, S-ketamine (esketamine), has recently been approved for the clinical management of treatment-resistant depression. As with ketamine, the non-selective opioid receptor-interacting drug buprenorphine is reported to have antidepressant and anxiolytic properties in humans and rodents. Given the fact that antidepressant drugs are also first line treatment for panic disorder, it is surprising that the potential panicolytic effect of these compounds has been scarcely (ketamine), or not yet (buprenorphine) investigated. We here evaluated the effects of ketamine (the racemic mixture), esketamine, and buprenorphine in male Wistar rats submitted to a panicogenic challenge: acute exposure to hypoxia (7% O2). We observed that esketamine (20 mg/kg), but not ketamine, decreased the number of escape attempts made during hypoxia, and this effect could be observed even 7 days after the drug administration. A panicolytic-like effect was also observed with MK801, which like esketamine, antagonizes NMDA glutamate receptors. Buprenorphine (0.3 mg/kg) also impaired hypoxia-induced escape, an effect blocked by the non-selective opioid receptor antagonist naloxone, indicating an interaction with classical ligand sites, such as µ and kappa receptors, but not with nociception/orphanin FQ receptors. Altogether, the results suggest that esketamine and buprenorphine cause rapid-onset panicolytic-like effects, and may be alternatives for treating panic disorder, particularly in patients who are refractory to standard pharmacological treatment. Department of Pharmacology School of Medicine of Ribeirão Preto University of São Paulo Department of Biomolecular Sciences School of Pharmaceutical Sciences University of São Paulo Aarhus Institute of Advanced Studies (AIAS) Aarhus University Behavioural Neurosciences Institute (INeC) Department of Pharmacology and Therapeutics State University of Maringá (UEM) Department of Biological Sciences School of Sciences São Paulo State University (UNESP) Department of Biological Sciences School of Sciences São Paulo State University (UNESP) CNPq: 142509/2018-3 FAPESP: 2018/00153-5
Databáze: OpenAIRE
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