CYP2A6, CYP1A1, and CYP2D6 polymorphisms in lung cancer patients from Central South China
| Autor: | Fang-dan Ou-yang, Hanchun Chen, Xinxing Wan, Feng-mao Huang, Fu-lan Yang, Dianzheng Zhang, Ai-hua Xu, Md. Asaduzzaman Khan |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male China Cancer Research medicine.medical_specialty Lung Neoplasms Biology Cytochrome P-450 CYP2A6 Internal medicine Genotype Biomarkers Tumor Cytochrome P-450 CYP1A1 medicine Carcinoma Genetic predisposition Humans Lung cancer CYP2A6 Genetics Polymorphism Genetic Hematology Multifactor dimensionality reduction General Medicine Middle Aged respiratory system medicine.disease Lung cancer susceptibility Cytochrome P-450 CYP2D6 Oncology Case-Control Studies Female Aryl Hydrocarbon Hydroxylases |
| Zdroj: | Medical Oncology. 30 |
| ISSN: | 1559-131X 1357-0560 |
| DOI: | 10.1007/s12032-013-0521-z |
| Popis: | Lung cancer is a common cause of cancer-related death. The link between risk of lung cancer susceptibility and genetic polymorphisms in metabolic enzymes is well documented. In this study, the relationships between lung cancer susceptibility and polymorphisms in the phase I metabolic enzyme genes CYP1A1, CYP2D6, and CYP2A6 were investigated. Genomic DNA was isolated from the peripheral blood of 201 healthy controls and 168 lung carcinoma patients from the Han ethnic group of Hunan Province in Central South China. Polymorphisms of the investigated genes were analyzed using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and two-step allelic-specific PCR assays. No significant differences were found between the frequencies in cases and controls for the genotypes wild-type (WW), heterozygous mutant, or homozygous mutant; for CYP1A1 or CYP2D6; or for the genotypes WW, heterozygous deletion, or null genotype for CYP2A6. The three-locus model (CYP2A6/CYP1A1/CYP2D6) had a maximum test sample accuracy that was significant (P |
| Databáze: | OpenAIRE |
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